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Here, a nanotherapeutic approach is reported using self\u2010assembled poly\u2010curcumin nanoparticles (PCur\u2010SANPs) formed by alkali\u2010catalyzed polymerization and then fine\u2010tuned by electrochemical modulation to enrich bioactive surface moieties. Time\u2010resolved\n                    <jats:sup>1<\/jats:sup>\n                    H NMR and LDI\u2010TOF MS show the formation and controlled evolution of phenolic derivatives, including phenol, cinnamyl alcohol, gentisyl alcohol, and vanillic acid, which correlate with maximal antioxidant capacity and cytokine suppression at an optimized treatment window (PCur\u2010SANPs\n                    <jats:sub>30<\/jats:sub>\n                    ). In lipopolysaccharide (LPS)\u2010stimulated models, PCur\u2010SANPs\n                    <jats:sub>30<\/jats:sub>\n                    reduced TNF\u2010\u03b1 and IL\u20106 by more than 60% and inhibited nuclear factor kappa B (NF\u2010\u03baB) p65 nuclear translocation, indicating pathway\u2010level modulation of the inflammatory response. In vivo, PCur\u2010SANPs\n                    <jats:sub>30<\/jats:sub>\n                    alleviated clinical symptoms, preserved organ function, and improved survival to \u224880\u201385% in an LPS\u2010induced sepsis model, outperforming free curcumin. This work establishes a simple, mechanism\u2010guided electrochemical strategy for interfacial editing of nature\u2010derived nanomaterials, transforming curcumin into a stable, bioactive platform. The demonstrated reduction of systemic inflammation and the survival benefit position PCur\u2010SANPs as promising candidates for sepsis therapy and other inflammation\u2010driven disorders.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503627","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:38:57Z","timestamp":1762763937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulating Bioactive Moieties on Self\u2010Assembled Poly\u2010Curcumin Nanoparticles via Electrochemical Tuning to Attenuate Inflammation in Sepsis"],"prefix":"10.1002","volume":"15","author":[{"given":"Chin\u2010Jung","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Analytical and Environmental Sciences National Tsing Hua University  Hsinchu 30013 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fen","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Analytical and Environmental Sciences National Tsing Hua University  Hsinchu 30013 Taiwan"},{"name":"Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University  Hsinchu 30013 Taiwan"},{"name":"School of Pharmacy College of Pharmacy Kaohsiung Medical University  Kaohsiung 80708 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-1129","authenticated-orcid":false,"given":"Chih\u2010Ching","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmacy College of Pharmacy Kaohsiung Medical University  Kaohsiung 80708 Taiwan"},{"name":"Department of Bioscience and Biotechnology National Taiwan Ocean University  Keelung 20224 Taiwan"},{"name":"Center of Excellence for the Oceans National Taiwan Ocean University  Keelung 20224 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpaic.2024.04.003"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817633.ch18"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01635-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1552244"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07256-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104921"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0290"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1456403"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2016-0223"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00975"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-020-00922-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14080672"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030689"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112737"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11123270"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07987"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/b816681c"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.01.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(02)00323-X"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122791"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA24256A"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08402-y"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.06.011"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01770C"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b01323"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA24256A"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063075"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2010.532493"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2017.08.006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00632"},{"key":"e_1_2_8_33_1","first-page":"19","volume":"147","author":"Kim J. 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