{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:05:48Z","timestamp":1792325148168,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Short residence time and off\u2010target accumulation restrict ocular posterior delivery via topical administration. How to improve posterior drug delivery through non\u2010invasive method is the issue to be addressed. Inspired by the higher posterior delivery efficiency of conjunctival\u2010scleral pathway and hydrophilicity\u2010related tissue preference, the objective is to verify the feasibility of altering posterior tissue distribution via conjunctival\u2010scleral pathway by tuning nanoparticles (NPs) hydrophilicity. Herein, triamcinolone acetonide\u2010loaded NPs with different surface hydrophilicity were prepared by mixing poly(lactide\u2010co\u2010glycolide) and poly(lactide\u2010co\u2010glycolide)\u2010polyethylene glycol (PLGA\u2010PEG) at different ratios. 3.5% and 16.7% PEG NPs displayed 1.5\u2010 and 1.8\u2010fold higher sclera\n                    <jats:italic>\n                      P\n                      <jats:sub>app<\/jats:sub>\n                    <\/jats:italic>\n                    than 0% PEG NPs. Furthermore, the higher the surface hydrophilicity, the more NPs in conjunctiva but less in cornea, 3.5% and 16.7% PEG NPs showed 1.4\u2010 and 1.8\u2010fold higher choroid\u2010retina distribution than 0% PEG NPs via conjunctival\u2010scleral pathway. The higher posterior delivery was confirmed by enhanced therapeutic efficacy in vascular endothelial growth factor\u2010induced retinal neovascularization rabbit model. After dropped twice daily for 14 days, 3.5% and 16.7% PEG NPs reached comparable therapeutic effect with intravitreal injection. This study demonstrated the significance of NPs surface hydrophilicity in posterior delivery, providing theoretical basis for rational design of NPs for ocular posterior diseases therapy by topical dropping.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503628","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:22:01Z","timestamp":1773642121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Effect of Surface Hydrophilicity of Nanoparticles on Ocular Posterior Transport Pathway via Non\u2010Invasive Topical Administration"],"prefix":"10.1002","volume":"15","author":[{"given":"Yidan","family":"Wei","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Key Laboratory of Intelligent Mucosal Drug Delivery Systems Shenyang Pharmaceutical University  Shenyang 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