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Effective regulation of chronic inflammation, oxidative stress, and hydration levels is essential for achieving satisfactory DW healing. Drawing inspiration from the potent moisturizing properties of natural tremella polysaccharides (TP), we developed a 3D\u2010printed scaffold (LZ@TMG) tailored for DW repair. Specifically, this study combined nitric oxide (NO) nanoreactors (L\u2010Arg@ZIF\u20108) and gallium ions (Ga\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ) into a UV\u2010curable TP (TrepMA) to form a composite bioink, which was 3D\u2010printed into LZ@TMG scaffolds. These scaffolds effectively release NO and Ga\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    to inhibit bacterial growth during the early phase of wound healing. In the subsequent inflammatory and proliferative phases, the LZ@TMG scaffold modulates oxidative stress and inflammation while promoting angiogenesis. Furthermore, TP binds to Nrf2 to activate downstream endogenous antioxidant pathways, thereby enhancing intracellular antioxidant enzyme levels. In a mouse DW model, LZ@TMG reduced inflammation, promoted blood vessel and hair follicle regeneration, and accelerated wound healing. Furthermore, it enhanced aquaporin expression, improved skin hydration, and expedited re\u2010epithelialization. Collectively, this study introduces a multifunctional 3D\u2010printed scaffold inspired by natural moisturizing polysaccharides, providing a promising strategy for effective moist wound healing in diabetes.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503657","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:11:08Z","timestamp":1768893068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["3D\u2010Printed Hydrating Masque for Diabetic Wounds Repair: A Nitric Oxide\u2010Enhanced Tremella Polysaccharide\u2010Based Scaffold for Improved Wound Comprehensive Regulation"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiabao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Affiliated Hospital of Nantong University Medical School of Nantong University  Nantong 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