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Implanted devices that facilitate controlled, localized delivery of NSAIDs could sustain higher drug concentrations at the surgical site and extend pain management efficacy beyond oral or intravenous methods. Meloxicam\u2010loaded poly(ester urea) (PEU) nanofibers are fabricated with variations in polymer molecular mass, additives, additive loads, and substrate thickness to assess their respective influence on sustained meloxicam release. Nanofiber mats loaded with meloxicam and sodium bicarbonate demonstrated superior pain inhibition for three days over intraperitoneal (IP) and intramuscular (IM) injections of meloxicam in a murine tibial fracture pain model. Biopsies of muscle tissue surrounding the fracture, one day post\u2010treatment, possessed high meloxicam concentrations relative to plasma and significantly reduced Ptgs2 expression and COX\u20102 inhibition. This work demonstrates the extended performance of local meloxicam\u2010loaded PEU implants with significant pain and inflammation suppression.<\/jats:p>","DOI":"10.1002\/adhm.202503669","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:43:56Z","timestamp":1763966636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Additive Accelerated Meloxicam Release from Poly(Ester Urea) Fiber Implants for Acute Pain Management"],"prefix":"10.1002","volume":"15","author":[{"given":"Courtney S.","family":"Dziewior","sequence":"first","affiliation":[{"name":"Department of Chemistry Duke University  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yize","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Translational Pain Medicine Department of Anesthesiology Duke University School of Medicine  Durham North Carolina 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