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An innovative electrostatically self\u2010assembled microalgae facial mask (MCSM) via a scalable chitosan (CS)\u2010microalgae flocculation strategy is proposed. The rod\u2010shaped morphology of\n                    <jats:italic>Synechococcus elongatus<\/jats:italic>\n                    provides extensive surface area for stable substrate immobilization and efficient loading of bioactive molecules, while its well\u2010established photosynthetic capability enables sustained oxygen generation to counteract local hypoxia. Through electrostatic attraction between cationic CS and anionic\n                    <jats:italic>S. elongatus<\/jats:italic>\n                    , robust photosynthetic microalgae coatings are constructed on diverse mask substrates while preserving algal bioactivity. Modulating surface electronegativity enables efficient loading of berberine (Bbr), achieving sustained drug release (12\u00a0h antibacterial rates: 99.98%\u201399.84% against MRSA,\n                    <jats:italic>E. coli<\/jats:italic>\n                    , and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ) and rapid photodynamic sterilization under white light (20\u00a0min: 99.98% against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , 97.69% against\n                    <jats:italic>P. acnes<\/jats:italic>\n                    ). The microalgae neutralize excess ROS, mitigating phototoxicity and supplying oxygen to accelerate healing. In vivo, MCSM\u2010Bbr promotes near\u2010complete wound closure in MRSA\u2010 (100%) and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    \u2010infected (95.15%) wounds by day 14 via pathogen eradication, anti\u2010inflammation, and enhanced collagen deposition. This strategy's universality is further demonstrated by extending it to diverse microalgae and substrates. The work pioneers a non\u2010antibiotic skincare strategy\u00a0integrating microbial activity with materials science.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503707","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T04:51:13Z","timestamp":1771217473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrostatically Self\u2010Assembled Microalgae Facial Masks for Dual\u2010Functional Therapy: Anti\u2010Infection and Healing Promotion"],"prefix":"10.1002","volume":"15","author":[{"given":"Xinqin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Health Science and Biomedical Engineering Hebei University of Technology  Tianjin P. R. China"},{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory For the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan P. R. China"},{"name":"School of Materials Science &amp; Engineering Peking University  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Health Science and Biomedical Engineering Hebei University of Technology  Tianjin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congyang","family":"Mao","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory For the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5994-1565","authenticated-orcid":false,"given":"Shuilin","family":"Wu","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory For the Green Preparation and Application of Functional Materials School of Materials Science &amp; Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan P. R. China"},{"name":"School of Materials Science &amp; Engineering Peking University  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Materials Science &amp; Engineering Peking University  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengli","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Materials Science &amp; Engineering the Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China Tianjin University  Tianjin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science &amp; Engineering the Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China Tianjin University  Tianjin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Materials Science &amp; Engineering the Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China Tianjin University  Tianjin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenduo","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Materials Science &amp; Engineering the Key Laboratory of Advanced Ceramics and Machining Technology By the Ministry of Education of China Tianjin University  Tianjin P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Spine Surgery Department of Spine Surgery Peking University Shenzhen Hospital  Shenzhen P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6469-2363","authenticated-orcid":false,"given":"Xiangmei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Health Science and Biomedical Engineering Hebei University of Technology  Tianjin P. R. 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