{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:06:43Z","timestamp":1790140003165,"version":"4.0.1"},"reference-count":77,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Recent advances in three\u2010dimensional bioprinting (3DBP) technology enable the production of customized bone substitutes. However, osteoconductive materials in their particulate phase may damage cells during extrusion resulting in poor cell viability after 3DBP. We developed a cell\u2010friendly, osteopromotive, and antibacterial\u2010based bioink. To achieve this, we combined gelatin methacryloyl (GelMA) with an Ag\u2010doped bioactive glass\u2010ceramic (Ag\u2010BaG) on the molecular level with (3\u2010Glycidoxypropyl) trimethoxysilane (GPTMS) to deliver a GelMA\u2010AgBaG (GAB) hybrid material and compared its characteristics with GelMA and a GelMA\u2010AgBaG blend nanocomposite. Elemental homogeneity was observed by scanning electron microscopy (SEM\u2010EDS) in GAB. Rheological studies exhibited strong shear\u2010thinning and high storage moduli. The swelling and degradation behavior up to 30 days demonstrated the materials' applicability for short\u2010term applications. The cytocompatibility of GAB, along with its antibacterial properties, was observed, with only 2% of cell death compared to 5% for the pure GelMA, and about 35% for the blend (GelMA\u2010Ag\u2010BaGNPs), according to the post\u2010extrusion cell viability. Extruded constructs and bioprinted scaffolds showed metabolic activity and cell viability over time, with the cell\u2010laden GAB presenting improved cell viability when compared to GelMA and the nanocomposite blend. Thus, hybrid material GAB possesses advanced multifunctional characteristics suggesting GAB as attractive biomaterial for tissue regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202503722","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:52:17Z","timestamp":1790139137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Bioactive Glass\u2010Based Hybrid Bioink With Enhanced Cell Viability and Antibacterial Properties"],"prefix":"10.1002","author":[{"given":"Adam C.","family":"Marsh","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-3787","authenticated-orcid":false,"given":"Ehsanul","family":"Hoque Apu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Northeast Ohio Medical University  Rootstown Ohio USA"},{"name":"Institute for Quantitative Health Science &amp; 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Immunology Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt D.","family":"Hankenson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-8278","authenticated-orcid":false,"given":"Christopher H.","family":"Contag","sequence":"additional","affiliation":[{"name":"Institute for Quantitative Health Science &amp; Engineering (IQ) Department of Biomedical Engineering Michigan State University East Lansing Michigan USA"},{"name":"Department of Microbiology, Genetics &amp; Immunology Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-6055","authenticated-orcid":false,"given":"Nureddin","family":"Ashammakhi","sequence":"additional","affiliation":[{"name":"Institute for Quantitative Health Science &amp; 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