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In our previous study, we demonstrated that discs of SiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010CaO\n                    <jats:sub>CME<\/jats:sub>\n                    \/poly(tetrahydrofuran)\/poly(caprolactone) hybrids or their dissolution products can drive terminal osteogenic differentiation of human bone marrow stromal cells (h\u2010BMSCs) in vitro. The current study shows that the 3D\u2010printed hybrid scaffolds with physiologically relevant 3D architecture further promote h\u2010BMSC osteogenesis. The 3D\u2010printed scaffolds support spatially organized cell behavior in an environment mirroring conditions relevant to off\u2010the\u2010shelf implant applications. Primary cellular functions, including viability, adhesion, and proliferation, were maintained across 3D scaffold surfaces and within inter\u2010strut regions. osteogenic commitment was evidenced by the upregulation of lineage\u2010specific transcripts, hydroxyapatite deposition, and the organized assembly of extracellular matrix (ECM)\u00a0proteins. Our results demonstrate that 3D\u2010printed scaffolds drive osteogenesis by modulating cell metabolism, inducing osteogenic morphological transitions, and promoting the expression of osteocalcin and collagen type I alpha 1 chain, alongside hydroxyapatite matrix mineralization. Collectively, our findings highlight the SiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010CaO\n                    <jats:sub>CME<\/jats:sub>\n                    \/poly(tetrahydrofuran)\/poly(caprolactone) scaffold's strong osteogenic properties\u2014driven by composition, surface architecture, and ion release \u2013 and its promise for clinical bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503733","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:11:51Z","timestamp":1770095511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["SiO\n                    <sub>2<\/sub>\n                    \u2010CaO\n                    <sub>CME<\/sub>\n                    \/Poly(Tetrahydrofuran)\/Poly(Caprolactone) 3D\u2010Printed Scaffolds Drive Human\u2010Bone Marrow Stromal Cell Osteogenic 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