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In this study, we have developed a dual\u2010layer metal\u2013organic framework (MOF) integrated microneedle patch (DMMN) designed to facilitate sequential dissolution for combination therapy, encompassing sensitized PTT, autophagy regulation, and chemotherapy. The outer layer of the microneedle is constructed from a hyaluronic acid (HA) matrix, which is integrated with carboxyl MOFs loaded with Apoptozole (Az), an Hsp70 inhibitor. This configuration maintains rapid dissolution behavior and exhibits favorable mechanical properties. The core layer consists of hyaluronic acid methacryloyl (HAMA), which encapsulates photothermal agents and degrades slowly to enable deep\u2010tissue penetration for effective PTT. The incorporated MOFs enhance the mechanical strength of the HA\u2010based microneedles and improve the loading efficiency of hydrophobic drugs. Upon tissue penetration, the released Az inhibits Hsp70, thereby sensitizing cancer cells to PTT, promoting lysosome\u2010mediated apoptosis, and suppressing autophagy. 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