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Endothelial dysfunction and hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) deficiency drive TAD progression, but existing H\n                    <jats:sub>2<\/jats:sub>\n                    S donors exhibit uncontrolled release and cytotoxicity. Herein, we developed a GSH\u2010responsive H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing polymer, named PSG12, using a gas\u2010click polymerization strategy under mild conditions. PSG12 achieved tunable H\n                    <jats:sub>2<\/jats:sub>\n                    S release (4.27\u2010fold higher at 2\u00a0m\n                    <jats:sc>m<\/jats:sc>\n                    than 0.5\u00a0m\n                    <jats:sc>m<\/jats:sc>\n                    GSH) and sustained plasma levels (more than 650\u00a0n\n                    <jats:sc>m<\/jats:sc>\n                    for 12\u00a0h post\u2010injection). In TNF\u2010\u03b1\u2010challenged endothelial cells, PSG12 reduced the level of ROS (77% reduction), suppressed senescence (92.4% reduction), inhibited apoptosis (63% reduction), reduced inflammation (29.35% decrease in IL\u20101\u03b2 protein expression), and preserved extracellular matrix (47.83% decrease in MMP\u20102 protein expression). In BAPN\u2010induced TAD mice, PSG12 reduced aortic rupture (from 53.3% to 20.0%), improved survival (from 46.7% to 80.0%). On the one hand, PSG12 restored the homeostasis of endothelial cells in multiple dimensions; on the other hand, PSG12 maintained the concentration of plasma H\n                    <jats:sub>2<\/jats:sub>\n                    S. This precision gas therapy platform enables multi\u2010pathway synergistic modulation for TAD.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503768","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:37:47Z","timestamp":1764830267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["H\n                    <sub>2<\/sub>\n                    S Click Delivery: Responsive Release for Multidimensional Therapy of Thoracic Aortic Dissection"],"prefix":"10.1002","volume":"15","author":[{"given":"Yunpeng","family":"Luo","sequence":"first","affiliation":[{"name":"Clinical School of Thoracic Department of Cardiovascular Surgery Tianjin Medical University Tianjin Chest Hospital  Tianjin P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-7067","authenticated-orcid":false,"given":"Weixun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xijing Hospital of Air Force Military  Xi'an P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical School of Thoracic Department of Cardiovascular Surgery Tianjin Medical University Tianjin Chest Hospital  Tianjin P. R. 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