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However, hiPSC\u2010CMs generated by the current methods still exhibit structural and electrophysiological immaturity, resembling fetal cardiomyocytes. Although various strategies have been developed to promote in vitro maturation, cell loss and death remain persistent challenges during transplantation. Therefore, a multipronged approach is developed to induce in situ hiPSC\u2010CMs functional maturation and enhance the cell transplantation rate, not only allowing cells carried within to have lower automatism, but also retaining the ability to restore systolic function. Chitosan is used as the matrix backbone to form a unique 3D network structure for cell encapsulation and delivery, whereas anionic lipid\u2010based carriers derived from negatively charged liposomes enabled pH\u2010responsive release of the mammalian target of rapamycin (mTOR) inhibitor within the weakly acidic microenvironment in myocardial infarction. 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This approach promotes the functional recovery of injured hearts by enhancing more robust gap junctions and angiogenesis in infarcted mouse hearts.<\/jats:p>","DOI":"10.1002\/adhm.202503799","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:35:52Z","timestamp":1761107752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inducing In Situ Functional Maturation of Transplanted Human Induced Pluripotent Stem Cell\u2010Derived Cardiomyocytes: Establishing Strategies for Treating Myocardial Injury"],"prefix":"10.1002","volume":"15","author":[{"given":"Xueqin","family":"Shi","sequence":"first","affiliation":[{"name":"The Tenth Affiliated Hospital (Dongguan People's Hospital) Shenzhen School of Clinical Medicine Southern Medical University  Dongguan 523059 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