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During liver fibrogenesis, lysyl oxidase enzymes become upregulated, which facilitate \u03b5 amino groups of lysine in extracellular matrix proteins to become oxidized, yielding the aldehyde\u2010containing allysine (Lys\n                    <jats:sup>Ald<\/jats:sup>\n                    ). In this context, a novel hydrazine\u2010functionalized gadolinium\u2010platinum nanoplatform (Pt@Gd\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    \u2010PEG\u2010N\n                    <jats:sub>2<\/jats:sub>\n                    H\n                    <jats:sub>4<\/jats:sub>\n                    ) has been engineered to facilitate accurate diagnosis and therapy of liver fibrosis. The platform achieves targeted delivery to activated hepatic stellate cells (aHSCs) via hydrazine\u2010mediated covalent binding to Lys\n                    <jats:sup>Ald<\/jats:sup>\n                    , which is enriched in fibrotic regions of the liver. Additionally, GPPN exhibits dual enzymatic activities analogous to catalase and peroxidase, providing oxygen to mitigate hypoxia in fibrotic liver tissues and generating highly toxic hydroxyl radicals (\u00b7OH) for the selective ablation of aHSCs. There are no significant adverse effects in histological or hematological evaluations. Moreover, GPPN improves magnetic resonance imaging (MRI) signals of liver fibrosis to enable more accurate assessment of disease progression. Overall, GPPN presents considerable potential for the precise diagnosis and effective therapy of liver fibrosis.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503891","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T11:16:11Z","timestamp":1764760571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered Gadolinium\u2010Decorated Magnetic Resonance Nanoprobes for Enhanced Liver Fibrosis Theranostics"],"prefix":"10.1002","volume":"15","author":[{"given":"Yingqi","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Shandong First Medical University 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