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Due to altered circulation, reduced macrophage recruitment, and compromised immunity at early time points, skin wound healing is impaired in SCI patients. To promote macrophage recruitment, topical elastin\u2010like polypeptides (ELP) fused with \u03b1\u2010melanocyte\u2010stimulating hormone (MSH\u2010ELP) and monocyte chemoattractant protein\u20101 (MCP\u2010ELP) were developed. Constructs encoding MSH\u2010ELP or MCP\u2010ELP in a pET25b+ vector were transformed into E. coli for expression. Physical and biological in vitro assays were conducted to ensure that the fusion proteins exhibited the expected bioactivity; subsequently, they were tested as topical treatments on experimental skin wounds on SCI mice. SDS\u2010PAGE and western blot analysis confirmed single bands with molecular weights of 26.3\u00a0kDa (MSH\u2010ELP) and 33.4\u00a0kDa (MCP\u2010ELP), respectively, forming nanoparticles of 100\u2013250\u00a0nm in diameter at the tested concentrations, with a lack of toxicity. MSH\u2010ELP reduced lipopolysaccharide\u2010induced inflammation and enhanced the chemotactic response of THP\u20101 cells. In experimental skin wounds on SCI mice, the nanoparticles enhanced the recruitment of macrophages in a time\u2010dependent manner. We also observed a reduction in scar area and wound width, together with increased macrophage (M2) activity, increased angiogenesis, and extracellular matrix protein deposition in the wound area. In conclusion, we developed a nanoparticle system that demonstrates superior chemotactic response relative to its native form, maintains a safe biocompatibility profile, and significantly improves cutaneous wound healing in an SCI mouse model.<\/jats:p>","DOI":"10.1002\/adhm.202503910","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T10:36:53Z","timestamp":1774348613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Coacervates Made of Elastin\u2010Like Polypeptides Fused with Melanocyte\u2010Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord\u2010Injured Mice"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-8654","authenticated-orcid":false,"given":"Suneel","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Rutgers, The State University of 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