{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:10:13Z","timestamp":1789585813312,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Di\u2010(2\u2010ethylhexyl) phthalate (DEHP) is a prevalent plasticizer that has been demonstrated to induce male reproductive toxicity through the disruption of spermatogenesis. Icariin (ICA), a bioactive compound derived from the traditional Chinese medicine Epimedium, holds significant potential in the treatment of male infertility. However, its clinical utilization is constrained by low absorption and fast metabolism upon oral administration. Herein, we first developed ICA\u2010loaded chondroitin sulfate (CS) and polyvinylpyrrolidone K30 (PVP K30) microneedle (MN) patches (ICA MNs) for treating DEHP\u2010induced testicular dysfunction. The results found that ICA MNs significantly reduced DEHP\u2010induced oxidative stress and apoptosis in GC\u20101 cells by modulating the Keap1\/Nrf2\/HO\u20101 pathway. In addition, ICA MNs mitigated DEHP\u2010induced testicular damage, sperm irregularities, and blood\u2010testis barrier impairment in rats, surpassing the efficacy of oral ICA treatment. Proteomic analysis indicated a restoration of the testicular proteome toward normal levels after ICA MN treatment. Comprehensive safety assessments revealed no adverse systemic effects, highlighting the biocompatibility of ICA MNs. These findings suggest ICA MNs as a promising therapeutic approach for male infertility associated with DEHP exposure, offering targeted and efficient transdermal delivery.<\/jats:p>","DOI":"10.1002\/adhm.202503925","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:02:46Z","timestamp":1764320566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transdermal Delivery of Icariin via Microneedle Patches Attenuates Phthalate\u2010Induced Testicular Injury"],"prefix":"10.1002","volume":"15","author":[{"given":"Chunyan","family":"Fang","sequence":"first","affiliation":[{"name":"Institute of Quality Standard and Testing Technology For Agro\u2010Products Sichuan Academy of Agricultural Sciences  Chengdu China"},{"name":"Tea Research Institute Sichuan Academy of Agricultural Sciences  Chengdu 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