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In this work, we developed a dynamic slide\u2010ring supramolecular hydrogel with dual molecular innovations: a dityrosine (DY)\u2010driven pH\u2010responsive fluorescence core in four\u2010arm PEG (4A\u2010PD) and Arginine\u2010Glycine\u2010Aspartic acid peptide (RGD) peptide\u2010functionalized hyperbranched polyglycerol (HPG)\u2010modified \u03b1\u2010cyclodextrin (CHR) for enhanced cell adhesion and drug loading. The host\u2010guest interactions between 4A\u2010PD and CHR form a network with shear\u2010thinning, rapid self\u2010healing, and UV\u2010triggered covalent stabilization, enabling room\u2010temperature extrusion\u2010based 3D printing. The printed constructs exhibit high shape fidelity and porous architectures that promote RGD\u2010mediated cell adhesion and proliferation. The DY core imparts the hydrogel with pH\u2010dependent blue fluorescence (emission peak: 400\u00a0nm), allowing real\u2010time microenvironmental monitoring. HPG modification of \u03b1\u2010CD significantly enhances the drug\u2010loading capacity, demonstrated by the sustained release of tobramycin (TOB) for effective infection control. In a full\u2010thickness infected rat wound model, the TOB\u2010loaded hydrogel accelerates wound closure (97.67% \u00b1 0.56% by day 14), promotes collagen deposition, and modulates inflammation (reduced IL\u20106, increased IL\u201010), while enhancing angiogenesis. This multifunctional hydrogel integrates 3D printing, drug delivery, and responsive sensing, offering a versatile platform for regenerative medicine.<\/jats:p>","DOI":"10.1002\/adhm.202503936","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:23:03Z","timestamp":1768893783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dynamic Slide\u2010Ring Hydrogels with Dityrosine\u2010Driven pH\u2010Responsive Fluorescence: Enabling 3D Printing, Enhanced Drug Delivery and Regenerative Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yong","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology  Kunming Yunnan 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