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We innovatively developed a lactose\u2010modified, self\u2010assembled, and NIR\u2010responsive type\u2010I photosensitizer, BDPL, with precise HepG2\u2010targeting ability. Multiglycosylation enables the efficient generation of O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\u2022<\/jats:sup>\n                    via the regulation of carbohydrate\u2012carbohydrate interactions (CCIs) among neighboring lactose units in the nanoaggregates, enabling BDPLs to be used for NIR\u2010responsive type I photodynamic therapy (PDT) and photothermal therapy (PTT). Concurrently, to address the inherent limitations of conventional phototherapy, specifically inadequate tissue penetration and profound tumor hypoxia, we engineered\n                    <jats:bold>ABDPL@Fe NPs<\/jats:bold>\n                    through the strategic loading of hydrophobic artemisinin (ARTE) with amphoteric BDPL followed by Fe(III) coordination, establishing a synergistic therapeutic platform for increased tumor suppression. This innovative nanoplatform serves as a nanogenerator of carbon\u2010centered and hydroxyl radicals under hypoxic and light\u2010deprived conditions, revealing significant potential for treating deep\u2010seated tumors with hypoxic microenvironments. For the first time, we report a glycosylated NIR\u2010activated nanoplatform that unleashes a ROS storm to disrupt tumor antioxidant defenses, inducing synergistic apoptosis\u2013ferroptosis death. This strategy has antitumor efficacy and improves precision\u2010targeted treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202503975","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:37:49Z","timestamp":1764830269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glycosylated Multifunctional Nanoplatform Co\u2010Delivering Artemisinin: Synergizing NIR\u2010Responsive Phototherapy with Chemodynamic Therapy for Precision\u2010Targeted Tumor Theranostics"],"prefix":"10.1002","volume":"15","author":[{"given":"Gai\u2010li","family":"Feng","sequence":"first","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 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