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Herein, through three cascaded molecular engineering steps, a hyperbranched polymer based covalently linked micelle is developed to show highly broad\u2010spectrum aPDT efficacy. First, through precise molecular structural optimization, a conjugated hyperbranched polymer photosensitizer\n                    <jats:bold>TSeHP<\/jats:bold>\n                    with far\u2010red\/near\u2010infrared emission and high reactive oxygen species (ROS) generation efficiency is developed and synthesized from an AB\n                    <jats:sub>2<\/jats:sub>\n                    \u2010type monomer, which is also featured with large number of terminal alkyne groups in its periphery. Subsequently, through azide\u2010alkyne click chemistry reaction, TSeHP is decorated with polyethylene glycol (PEG) to form covalently linked micelles TSeHP\u2010PEG with much better stability during biomedical applications, as compared to conventional micelles or nanoparticles. Finally, to further confer targeting capability and inherent antibacterial properties, TSeHP\u2010PEG is covalently conjugated with a hydrophilic antimicrobial peptide, yielding TSeHP\u2010P with good biocompatibility. Microbiological assays demonstrate that TSeHP\u2010P enables real\u2010time imaging and exhibits potent broad\u2010spectrum antibacterial photodynamic activity against pathogens, including methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), via membrane disruption. Moreover, TSeHP\u2010P demonstrates excellent performance in accelerating the healing process of MRSA\u2010infected wounds in rats, showing good potential in infective therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504005","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T05:40:41Z","timestamp":1761370841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conjugated Hyperbranched Polymer Photosensitizer Based Covalently Linked Micelles for Broad\u2010Spectrum Bacterial Treatment"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiabao","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Chemistry Institute of Molecular Aggregation Science Tianjin University  Tianjin 300072 P. R. 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