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Microneedles provide a minimally invasive transgingival delivery route that enables efficient drug administration to deep periodontal sites. Here, an innovative hyaluronic acid\u2010based microneedle system loaded with MXene\u2010Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    nanocomposites (FM\u2010MN) has been developed to provide phase\u2010specific therapy for periodontitis. In the bacterial accumulation phase, near\u2010infrared (NIR) irradiation triggers synergistic antibacterial action through MXene\u2010mediated photothermal effects and Fe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced ferroptosis\u2010like bacterial death, eradicating biofilms at mild temperatures. In the tissue regeneration phase, the same system\u2010without irradiation\u2010 leverages the unique properties of MXene to scavenge reactive oxygen species, modulate inflammation, and promote osteogenic differentiation. RNA sequencing further reveals the underlying anti\u2010inflammatory and osteogenic mechanisms of this composite. In a rat periodontitis model, FM\u2010MN significantly reduces inflammation and restores alveolar bone. This work presents a dual\u2010action strategy for periodontitis but also offers a versatile microneedle\u2010based platform for other complex conditions requiring sequential treatment regimens.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504030","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:50:59Z","timestamp":1762505459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Multifunctional MXene\u2010Fe Composite Microneedle System for Phase\u2010Specific Periodontitis Therapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2721-3511","authenticated-orcid":false,"given":"Dan","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Sichuan University  Chengdu 610041 China"},{"name":"Department of 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