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Traditional Chinese medicine herbs (TCMH) offer unique advantages in this area due to its multi\u2010component, multi\u2010target, and synergistic therapeutic mechanisms. Nevertheless, the poor solubility, limited bioavailability, and instability of many active compounds remain significant barriers to clinical application. Recent progress in self\u2010assembling nanomaterials offers a promising solution to these challenges. During the full lifecycle of TCMH, including harvesting, processing, decoction, and in vivo metabolism, bioactive components such as polysaccharides, flavonoids, and saponins can spontaneously assemble into nanostructures via non\u2010covalent interactions. Self\u2010assembled systems enhance solubility, stability, and intestinal permeability, facilitate bone\u2010targeted and controlled drug release, and ultimately improve therapeutic efficacy with reduced systemic toxicity. This review systematically elucidates the formation pathways, key active components, and structural characteristics of self\u2010assembled nanomaterials during the processes of fresh TCMH, herbal processing, herbal decoction, traditional Chinese medicine (TCM) preparation, and in vivo disposition, from the holistic perspective of TCMH. It focuses on their roles in regulating bone metabolism and promoting osteogenesis. Additionally, the article highlights cutting\u2010edge methods of integrating these nanostructures with advanced technologies such as 3D printing and AI\u2010assisted design, emphasizing their potentially transformative value in achieving precise individualized osteoporosis treatment and advancing the modernization and mechanistic research of TCMH. Together, these insights not only provide new strategies for precise and personalized osteoporosis management but also chart a pathway toward the scientific modernization and global translation of TCMH.<\/jats:p>","DOI":"10.1002\/adhm.202504047","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T11:40:17Z","timestamp":1765971617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self\u2010Assembled Nanomaterials from a Holistic Perspective of Chinese Herbal Medicine: Accessibility and Efficacy in Anti\u2010Osteoporosis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yanjun","family":"Yang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Pharmacy, Innovation Center for Industry\u2010Education Integration of Pediatrics and Traditional Chinese Medicine, Affiliated Jiangning Hospital of Chinese Medicine China Pharmaceutical University  Nanjing 211198 P.R. 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