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Traditional wound dressings, while partially promoting healing, often lack the integrated functions of antibacterial properties, antioxidant capabilities, and inflammation regulation, making them insufficient for complex wound environments. This study developed a freeze\u2010dried dual\u2010network sponge by cross\u2010linking platelet\u2010rich plasma (PRP) and cerium oxide (CeO\n                    <jats:sub>2<\/jats:sub>\n                    ) into a silver ion carboxymethyl agarose (CMA\u2010Ag) matrix. The sponge not only exhibits excellent water absorption and compressive strength but also demonstrates comprehensive regulatory capabilities throughout the entire wound healing process. It has remarkable antibacterial properties, effectively mitigates oxidative stress injury, and continuously regulates the inflammatory microenvironment of infected wounds. Moreover, the material promotes the N2 polarization of neutrophils via the Toll\u2010like receptor\/nuclear factor\u2010\u03baB (TLR\/NF\u2010\u03baB) signaling pathway, subsequently inducing the polarization of macrophages towards the anti\u2010inflammatory M2 phenotype. This significantly accelerates wound healing and tissue regeneration, particularly in epithelialization and angiogenesis. The freeze\u2010dried sponge also offers unique advantages, including long\u2010term storage, personalized customization, and on\u2010the\u2010shelf availability. In summary, this multifunctional freeze\u2010dried sponge provides an efficient, convenient, and personalized solution for the comprehensive management of infected wounds, with significant potential for clinical application.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504053","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T06:55:04Z","timestamp":1766213704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Multifunctional CeO\n                    <sub>2<\/sub>\n                    \u2010Modified Dual\u2010Network Freeze\u2010Dried Sponge for Infected Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Yutian","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  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