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These devices are largely constructed from polymeric materials, and despite advancements in material biocompatibility, remain susceptible to adverse biological processes such as thrombosis, inflammation, and calcification, introducing risks to patient safety and constraining long\u2010term device performance. This article builds on previous research that introduced a plasma\u2010mediated zwitterion surface modification by chemically cross\u2010linking the zwitterionic graft to improve graft stability, examining biological responses to these modifications, and adapting the protocol to device geometries. By chemically cross\u2010linking the zwitterionic graft with a specific zwitterion:crosslinker ratio, the stability of the graft can be extended without compromising its functional efficacy. These cross\u2010linked zwitterion grafts drive reductions in 1) thrombus formation in static and dynamic in vitro models, 2) inflammatory responses via a mixture of in vitro inflammatory cytokine expression and in vivo M1 macrophage counts, and 3) mineral deposition via in vitro calcification assays. Finally, the grafting process can be applied to vascular and valvular geometries, highlighting its translational potential to a range of medical devices.<\/jats:p>","DOI":"10.1002\/adhm.202504078","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T08:25:42Z","timestamp":1764145542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010Linked Zwitterionic Surface Modifications for Biocompatible Blood\u2010Contacting Medical Devices"],"prefix":"10.1002","volume":"15","author":[{"given":"Matthew","family":"Crago","sequence":"first","affiliation":[{"name":"School of Chemical and Biomolecular Engineering University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Faculty of Health and Medicine Charles Perkins Centre University of Sydney 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