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This study introduces cobalt phosphide nanoparticles deposited on carbon polyhedral frameworks (CoP\u2010C PFs) as a multifunctional nanoplatform integrating enzyme\u2010mimicking catalysis and photothermal activity for synergistic psoriasis management. CoP\u2010C PFs exhibit superior catalytic efficiency, with low Michaelis\u2010Menten constants (e.g.,\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>m<\/jats:sub>\n                    = 0.26 mM for H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition), enabling potent reactive oxygen species (ROS) scavenging to alleviate oxidative damage in RAW264.7 macrophages and HaCaT keratinocytes. Under 808 nm near\u2010infrared irradiation, CoP\u2010C PFs exhibit a high photothermal conversion efficiency of 68.6%, enabling precise control of the local temperature to generate localized hyperthermia to enhance catalytic ROS elimination and antibacterial activity. In an imiquimod\u2010induced psoriatic murine model, CoP\u2010C PFs alleviated inflammation by restoring redox balance, suppressing CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cell\/F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    macrophage infiltration, modulating IL\u201017A\/IL\u201023 and TNF\u2010\u03b1\/NF\u2010\u03baB pathways, and promoting M2 macrophage polarization (increased CD206\n                    <jats:sup>+<\/jats:sup>\n                    \/CD68\n                    <jats:sup>+<\/jats:sup>\n                    ratio), resulting in epidermal normalization and reduced abnormal keratinization without organ toxicity, underscoring effectiveness and biosafety. By integrating photothermal enhancement with multienzyme catalysis, this \u201call\u2010in\u2010one\u201d nanozyme platform enables dual regulation of oxidative stress and immune microenvironment, offering a promising therapeutic strategy for psoriasis and other inflammatory skin disorders.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504080","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T13:57:20Z","timestamp":1768053440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photothermal\u2010Augmented CoP\u2010Carbon Polyhedral Nanozyme: Redox Homeostasis and Immune Reprogramming Mediated Psoriasis Therapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4540-3601","authenticated-orcid":false,"given":"Beibei","family":"Liu","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target 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