{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:21:57Z","timestamp":1791483717438,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173143"],"award-info":[{"award-number":["52173143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371108"],"award-info":[{"award-number":["82371108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fungal keratitis (FK) is an extremely blinding infectious ocular surface disease. Clinically, there are three major challenges in the topic drug treatment of FK: poor corneal permeability, poor antifungal effect, and inability to simultaneously reduce the inflammation accompanying the infection. In this work, atomically dispersed Cu\u2010N\n                    <jats:sub>4<\/jats:sub>\n                    and Cu nanoclusters is designed loaded on the a small\u2010sized positively charged CDs (denoted as Cu\u2010SA\/NC@CDs) is designed to fabricate Cu\u2010Needs. The Cu\u2010Needs exhibited excellent corneal permeability, which could can temporarily open the tight connections between corneal cells. More importantly, Cu\u2010Needs achieve rapid fungal elimination and eradication through energy depletion in fungus in the early stage of FK. Subsequently, Cu\u2010Needs effectively eliminated ROS and alleviated the inflammation in cornea tissue. This work proposes a strategy for the whole\u2010process intervention of fungal keratitis by regulating the microenvironment of single\u2010atom centers and nanoclusters through a tandem effect and enhancing catalytic activity. Conclusively, the excellent biosafety (biocompatibility, irritancy, ocular local toxicity and systemic toxicity) made Cu\u2010Needs a great potential strategy in clinical treatment of FK and other serious infectious diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504085","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T11:03:37Z","timestamp":1765364617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cu\u2010Single Atoms\/Clusters\u2010Nanoenzymes Trigger and Integrate Tandem Effect to Synchronously Boost Antifungal and Anti\u2010Inflammation for Fungal Keratitis"],"prefix":"10.1002","volume":"15","author":[{"given":"Mengyang","family":"Zhao","sequence":"first","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Geng","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanrong","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-4540","authenticated-orcid":false,"given":"Jingguo","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital Henan Provincial People's Hospital People's Hospital of Zhengzhou University  Zhengzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30448-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202409"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S447138"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.12.001"},{"key":"e_1_2_9_6_1","volume":"16","author":"Mpakosi A.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20240004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11294"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1461278"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118762"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003559"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S90347"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106342"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/acfada"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202412341"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300324"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c03934"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02479-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03509-5"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c01042"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.07.005"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403399"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00203"},{"key":"e_1_2_9_24_1","article-title":"A Review of Corneal Blindness: Causes and Management","volume":"14","author":"Tidke S. C.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508125"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402659"},{"key":"e_1_2_9_27_1","first-page":"120","article-title":"Dual\u2010Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease","volume":"16","author":"Chu D.","year":"2024","journal-title":"Nanomicro Lett"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02499-0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404334"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101493"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03564-6"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006591"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c02290"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c08014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01538-y"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b02035"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22143"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202501076"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61198-y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c04243"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03497-6"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00421B"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18062-y"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202105186"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB00802F"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202509812"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-023-03536-6"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00456-z"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101998"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2022.2046423"},{"key":"e_1_2_9_51_1","article-title":"Pt single\u2010atom\u2010functionalized 2D Al\u2010TCPP MOF nanosheets for enhancedphotodynamic antimicrobial therapy","volume":"41","author":"He S.","year":"2025","journal-title":"Acta Phys\u2010Chim Sinca"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504085","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:01:51Z","timestamp":1773000111000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adhm.202504085"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504085","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04085"}}