{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:54:01Z","timestamp":1793040841877,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["S24ZS03048"],"award-info":[{"award-number":["S24ZS03048"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metal\u2013organic frameworks (MOFs) have great potential for the development of targeted drug delivery systems (DDSs) to improve the effectiveness of inhibiting HepG2 cells. Herein, inspired by the solvothermal synthesis method and the concept of designable assembly, MOF (UiO\u201066\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    ) is first doped by Fe\u2010Cu NPs to form Fe\u2010Cu@MOF and further modified with polydopamine (PDA) and folic acid (FA) to obtain Fe\u2010Cu@MOF\u2010PDA\u2010FA for the loading of resveratrol (RES). The Fe\u2010Cu@MOF\u2010PDA\u2010FA has desirable drug loading efficiency and excellent pH\u2010responsive release of RES. In vitro cellular experiments and 3D hepatoma cell microspheres model, the Fe\u2010Cu@MOF\u2010PDA\u2010FA not only showed low cytotoxicity but also post\u2010drug has a good inhibitory effect on HepG2. In addition, Fe\u2010Cu@MOF\u2010PDA\u2010FA could achieve good tumor penetration via FR\u2010mediated endocytosis, while showing good anticancer cellular activity and the ability to promote reactive oxygen species (ROS) generation. Therefore, RES@Fe\u2010Cu@MOF\u2010PDA\u2010FA has promising applications as pH\u2010responsive DDS in combination with chemodynamic therapy (CDT) for cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504093","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:38:14Z","timestamp":1763797094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["pH\u2010Sensitive Metal\u2013Organic Frameworks for the Improved Inhibition of HepG2 Cell via Folate Receptor\u2010Mediated Targeting and Cascaded CDT Effect"],"prefix":"10.1002","volume":"15","author":[{"given":"Chen","family":"Zhang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"},{"name":"Haihe Laboratory of Modern Chinese Medicine  Tianjin P. R. China"},{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyu","family":"Pu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"},{"name":"Haihe Laboratory of Modern Chinese Medicine  Tianjin P. R. China"},{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Teng","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"},{"name":"Haihe Laboratory of Modern Chinese Medicine  Tianjin P. R. China"},{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyi","family":"Li","sequence":"additional","affiliation":[{"name":"South Australian Immunogenomics Cancer Institute The University of Adelaide  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hezhao","family":"Bai","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"},{"name":"Haihe Laboratory of Modern Chinese Medicine  Tianjin P. R. China"},{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Lin","sequence":"additional","affiliation":[{"name":"Analytical Instrumentation Centre Tianjin University  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Analytical Instrumentation Centre Tianjin University  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"},{"name":"Haihe Laboratory of Modern Chinese Medicine  Tianjin P. R. China"},{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-2535","authenticated-orcid":false,"given":"Fei","family":"Tian","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"},{"name":"Haihe Laboratory of Modern Chinese Medicine  Tianjin P. R. China"},{"name":"State Key Laboratory of Component\u2010based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124370"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0tb02547j"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S197889"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201001840\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b06105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c22194"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u201001297\u20100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201906846"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201907652"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c10900"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.02.067"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c01460"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S330187"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805664"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8nr09107b"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cc04218e"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109328"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306178"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3sc03635a"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202001251"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09171"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.10.010"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.132869"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500860"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126328"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12894"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010022\u201004551\u20104"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.01.069"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.135100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c05330"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.09.034"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.11.011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116476"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102742"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00075"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c00581"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2015.08.061"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201602997"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.9b01383"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b11652"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134248"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804153"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121912"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr03135f"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.12.015"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2022.11.024"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03751"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2017.03.101"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c07262"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.09.043"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:01:27Z","timestamp":1774620087000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/adhm.202504093"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504093","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04093"}}