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However, their clinical translation remains limited by chemical instability and insufficient performance under physiological conditions. To address these issues, we adopted a post\u2010synthetic modification (PSM) strategy, coating SiO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles with ultrathin COF layers through Schiff\u2010base condensation of TAPP and PDCA. This core\u2013shell architecture provides stable and uniform particles while enabling precise incorporation of catalytic sites. As a result, the\n                    <jats:bold>\n                      SiO\n                      <jats:sub>2<\/jats:sub>\n                      @COF\n                    <\/jats:bold>\n                    platform markedly enhances photocatalytic NADH oxidation, with a turnover frequency (TOF) increase from 8.75 to 43.67\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    under normoxia and from 10.3 to 46.7\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    even under hypoxia, demonstrating its robust and oxygen\u2010independent catalytic efficiency. Furthermore, the system promotes efficient reactive oxygen species (ROS) generation, activates the caspase\u20103\/GSDME pathway, leading to photon\u2010controlled pyroptosis activation and a significant amplification of therapeutic efficacy. Overall, this metal\u2010free\n                    <jats:bold>\n                      SiO\n                      <jats:sub>2<\/jats:sub>\n                      @COF\n                    <\/jats:bold>\n                    nanoplatform combines rational design with enhanced catalytic activity and precise biological control, representing a promising advance toward next\u2010generation precision phototherapies.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504125","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:48:41Z","timestamp":1769064521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leveraging SiO\n                    <sub>2<\/sub>\n                    \u2010Infused COFs for PhotoPyro"],"prefix":"10.1002","volume":"15","author":[{"given":"Hyeonji","family":"Rha","sequence":"first","affiliation":[{"name":"Department of Chemistry Korea University  Seoul South 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