{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:26:47Z","timestamp":1783013207393,"version":"3.54.6"},"reference-count":52,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171026"],"award-info":[{"award-number":["82171026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Advanced implantable medical devices often need to integrate multiple functions onto one surface to meet the complex needs in vivo. The construction of glycocalyx bionic coatings that mimic the natural multifunctional glycocalyx barrier of blood vessels, intestines, and ocular surfaces is an emerging strategy for function integration. However, in practical application scenarios such as corneal bandage lens (CBL) for corneal injury treatment, bio\u2010enzymes from immune cells and bacteria can degrade the natural polymers constructing the glycocalyx bionic coating, such as hyaluronic acid, resulting in the loss of coating functionality. To address this issue, we propose an enzyme\u2010resistant glycocalyx bionic coating (ER\u2010GBC) strategy; by introducing baicalin as a hyaluronidase inhibitor into hyaluronic acid\u2010based GBCs, the coating can be resistant to hyaluronidase's disruption. Meanwhile, by the free radical scavenging and bacteriostatic properties of baicalin and the bactericidal properties of silver nanoparticles embedded into the coating, the multiple functional ER\u2010GBC of hydrophilic, anti\u2010bacterial, and anti\u2010inflammatory were realized. As a result, the ER\u2010GBC\u2010modified CBL achieved good therapeutic results in the rabbit model of bacterial keratitis. This ER\u2010GBC strategy, constructed by combining glycocalyx active ingredients with corresponding enzyme inhibitors, is expected to provide new methods for developing bionic coatings for medical devices and clinical translation.<\/jats:p>","DOI":"10.1002\/adhm.202504174","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:33:34Z","timestamp":1769603614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enzyme\u2010Resistant Glycocalyx Bionic Coating for Corneal Bandage Lens Surface Engineering"],"prefix":"10.1002","volume":"15","author":[{"given":"Zezhen","family":"Zhang","sequence":"first","affiliation":[{"name":"The Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shenzhen Longgang Otolaryngology Hospital &amp; Shenzhen Otolaryngology Research Institute  Shenzhen China"},{"name":"Center For Intelligent Biomedical Materials and Devices Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-0468","authenticated-orcid":false,"given":"Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"},{"name":"Translational Clinical Immunology Key Laboratory of Sichuan Province School of Medicine Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qu","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900368"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000331"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212787"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12465"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010120219\u2010054401"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040\u20104603.2022.tb00232.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.729260"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2538"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010022\u201004154\u20102"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424\u2010007\u20100212\u20108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00340.2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.03.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311283"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202424981"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.10.015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.161010"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c06332"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202414136"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002330"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00052.2009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.04.023"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00101"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CRJ04003X"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.028"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.035"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709788453078"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400407a"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201901875"},{"issue":"221","key":"e_1_2_9_31_1","first-page":"25","article-title":"Handbook of X\u2010Ray Photoelectron Spectroscopy","volume":"40","author":"Chastain J.","year":"1992","journal-title":"Perkin\u2010Elmer Corporation"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms130912036"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2017.36"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.04.051"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2011.12.005"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001512\u20107"},{"issue":"5","key":"e_1_2_9_37_1","first-page":"1568","article-title":"A Mussel\u2010Inspired Facile Method to Prepare Multilayer\u2010AgNP\u2010Loaded Contact Lens for Early Treatment of Bacterial and Fungal Keratitis","volume":"4","author":"Liu X.","year":"2018","journal-title":"ACS Biomaterials Science & Engineering"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45413"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/jbji.17705"},{"issue":"12","key":"e_1_2_9_40_1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041216","article-title":"Role of Macrophages in Wound Healing","volume":"14","author":"Willenborg S.","year":"2022","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194795"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.855022"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16\u201019882"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA02472H"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14113"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00504-1"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.2.28"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8549-4_5"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00067"},{"key":"e_1_2_9_50_1","first-page":"391","volume-title":"Inhibition of IL\u20101, IL\u20106, and TNF\u2010\u03b1 in Immune\u2010Mediated Inflammatory Diseases, Springer Seminars in Immunopathology","author":"M\u00f6ller B.","year":"2006"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2268-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001943"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12012"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:10:19Z","timestamp":1783012219000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":52,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/adhm.202504174"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504174","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04174"}}