{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:43:10Z","timestamp":1790908990447,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22005231"],"award-info":[{"award-number":["22005231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272072"],"award-info":[{"award-number":["52272072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bacterial infection and oxidative stress at wound sites can significantly impede the wound healing process. Curcumin, a versatile and abundant natural product, exhibits broad\u2010spectrum antibacterial and antioxidant properties and is under investigation as a promising wound healing agent. However, its inherent limitations, such as low water solubility and bioavailability, hamper its clinical applications. To overcome these challenges and improve biosafety, the development of nanoparticulate curcumin formulation has emerged as a promising strategy. Herein, a curcumin\u2011based metal\u2010organic framework (Cu\/Zn\u2010Cur MOF) was fabricated using a facile and efficient \u201cmixing\u2010diluting\u201d strategy, achieving precise control over particle size through straightforward concentration adjustments of the curcumin\u2010metal ion (Zn\n                    <jats:sup>2+<\/jats:sup>\n                    , Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ) complex. The resulting Cu\/Zn\u2010Cur MOFs, which exhibit a well\u2010distributed spherical morphology, demonstrate admirable antioxidant activity by effectively eliminating \u2022OH and \u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    radicals. Additionally, Cu\/Zn\u2010Cur MOFs display broad\u2010spectrum and robust antibacterial activity against both Gram\u2010positive and Gram\u2010negative bacteria. Furthermore, Cu\/Zn\u2010Cur MOFs were integrated into a tissue adhesive hydrogel to form a multifunctional wound dressing (PCEM). In vivo studies demonstrated that the biocompatible PCEM exhibited good therapeutic efficacy and promoted infected wound healing. Overall, this work reports a novel strategy for the synthesis of carrier\u2010free curcumin nanoparticles, providing an avenue to broaden the application of insoluble natural active polyphenols.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504183","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:06:11Z","timestamp":1769763971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Size\u2010Controllable Curcumin\u2010Based Metal\u2010Organic Framework\u2010Integrated Multifunctional Hydrogel for Wound Healing Through Antibacterial and Antioxidant Properties"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuxin","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology For Material Synthesis and Processing Wuhan University of Technology  Wuhan 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Processing Wuhan University of Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-8350","authenticated-orcid":false,"given":"Jing","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Technology For Material Synthesis and Processing Wuhan University of Technology  Wuhan 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