{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:41:13Z","timestamp":1791646873183,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetic wounds are trapped in a self\u2010perpetuating pathological triad of hypoxia, infection, and oxidative stressdisrupting physiological wound healing and causing recalcitrant nonhealing ulcerswhile conventional therapies, limited by static interventions and simplistic co\u2010delivery, fail to adapt to the spatiotemporally heterogeneous wound microenvironment and break this cycle; to address this, we engineered a microenvironment\u2010responsive closed\u2010loop hydrogel dressing by integrating Cu\u2010doped oxygen\u2010vacancy molybdenum oxide nanozymes (MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    (Cu)) and curcumin (Cur) into an oxidized alginatehyaluronic acid matrix: MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    (Cu) forms a self\u2010regenerative defect synergy via Mo\n                    <jats:sup>5+<\/jats:sup>\n                    \/Mo\n                    <jats:sup>6+<\/jats:sup>\n                    \u2010Cu\n                    <jats:sup>+<\/jats:sup>\n                    \/Cu\n                    <jats:sup>2+<\/jats:sup>\n                    dual redox cycles (oxygen vacancies (Vo) regenerate Cu\n                    <jats:sup>2+<\/jats:sup>\n                    \u2192Cu\n                    <jats:sup>+<\/jats:sup>\n                    , Cu\n                    <jats:sup>+<\/jats:sup>\n                    stabilizes Vo, decomposing 98.7% endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into O\n                    <jats:sub>2<\/jats:sub>\n                    in 24 h with sustained catalysis), Cur acts as a catalytic cofactor (chelating Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ) and antimicrobial (disrupting bacterial membranes) for &gt; 99.9% biofilm inhibition, and the pH\u2010responsive Schiff base\u2010crosslinked hydrogel (activated by diabetic wounds' alkaline pH 79) accelerates Schiff base hydrolysis to release nanozymes\/Cur and boost MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    (Cu)'s catalytic efficiency by 1.8\u2010fold, dynamically matching wound microenvironment demands.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504199","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:22:13Z","timestamp":1762766533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oxygen\u2010Vacancy\u2010Engineered Self\u2010Regenerative Nanozymes in Dual\u2010Signal\u2010Responsive Dynamic Hydrogels: A Closed\u2010Loop Therapeutic Strategy for Diabetic Wound Microenvironment Remodeling"],"prefix":"10.1002","volume":"15","author":[{"given":"Xianchun","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China"},{"name":"Department of Medicine The Affiliated Hospital of Qingdao University  Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine The Affiliated Hospital of Qingdao University  Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6803-7647","authenticated-orcid":false,"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 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