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While Janus dressings enable unidirectional exudate transport, current designs overlook the critical need for maintaining optimal wound humidity and providing on\u2010demand antibacterial\/anti\u2010inflammatory treatment to support repair. To address this, a self\u2010pumping trilayered dressing (GCSIP) is developed, integrating polyhexamethylene guanidine\u2010grafted triglycidyl glycerol ether (PHMG\u2010GTE)\u2010modified cotton, ibuprofen\u2010loaded silk fibroin (IBU\/SF), and polyurethane (PU). This architecture achieves autonomous, unidirectional fluid transport and drug release via a controlled reflux mechanism triggered upon full saturation of the cotton layer. A precisely engineered microporous array (400 \u00b5m pores, 6\u00a0mm spacing) is used to optimize directional transport and reflux efficiency. Upon saturation, partial reflux through the array facilitates the release of dissolved SF molecules and 87.6% of the encapsulated ibuprofen (IBU) within 72\u00a0h. The released components significantly reduced TNF\u2010\u03b1 and IL\u20106 expression in M1 macrophages by 90.4% and 87.6%, respectively. The in vivo results demonstrate excellent biocompatibility and nearly complete wound healing within 15 days, with a residual wound area ratio of only 0.8%. This study establishes an on\u2010demand exudate regulation and drug release mechanism for multifunctional dressings to accelerate wound recovery.<\/jats:p>","DOI":"10.1002\/adhm.202504202","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T07:51:32Z","timestamp":1762156292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trilayered Self\u2010Pumping Dressing with Micropore Array for Drug Backflow Release in Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bio\u2010based Fiber Materials Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bio\u2010based Fiber Materials Zhejiang Sci\u2010Tech 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