{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:35:57Z","timestamp":1786700157553,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Poly(2\u2010oxazoline) (POx) polymers are hydrophilic and biocompatible materials with tunable physicochemical properties for biomedical use. Postoperative hypotony, which currently lacks approved pharmacological or device\u2010based treatment, requires minimally invasive and controllable methods for temporary intraocular pressure restoration. Herein, we present a modular strategy to control POx aggregation via thermally triggered co\u2010assembly with thermoswitchable poly(2\u2010n\u2010propyl\u20102\u2010oxazoline) (PnPrOx) and hydrophilic PEG\u2010modified PnPrOx (PnPrOx\u2010PEG). These mixtures remain dissolved at low temperatures but aggregate at physiological temperatures because of the thermo\u2010switchable behavior of the PnPrOx segments, with PEG content modulating particle size, dispersibility, and fusion. Based on in vivo compositional screening in rabbits, we highlight a 98:2 (w\/w) PnPrOx:PnPrOx\u2010PEG formulation (POx2P) that induces transient intraocular pressure elevation without persistent turbidity or deposition. In a trabeculectomy\u2010induced hypotony model, POx2P restored intraocular pressure without adverse effects. Microscopy and in vivo imaging suggest that this formulation forms flow\u2010responsive aggregates that transiently occlude aqueous outflow pathways. We established a compositionally tunable and injectable POx platform for in situ aggregation and pressure modulation, offering a clinically relevant approach for localised intraocular therapy.<\/jats:p>","DOI":"10.1002\/adhm.202504206","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:47:56Z","timestamp":1775724476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modular Control of PEG\u2010Poly(2\u2010Oxazoline) Co\u2010Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-2476","authenticated-orcid":false,"given":"Yuji","family":"Tanaka","sequence":"first","affiliation":[{"name":"Age\u2010Adaptive Project for Centenarian Mobility, New Industry Creation Hatchery Center (NICHe) Tohoku University Sendai Miyagi Japan"},{"name":"Innovation Center of NanoMedicine (iCONM) Kawasaki Institute of Industrial Promotion Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine University of Tsukuba Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2205-6497","authenticated-orcid":false,"given":"Shigehito","family":"Osawa","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine (iCONM) Kawasaki Institute of Industrial Promotion Kawasaki Kanagawa Japan"},{"name":"Department of Biomedical Engineering Faculty of Life Science Toyo University  Asaka Saitama 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