{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:50:00Z","timestamp":1775641800651,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A major challenge in precision medicine is the development of advanced biomaterials for targeted intervention in precancerous states. Here, we introduce an interfacial bioengineering strategy to construct a dynamic network for programmed intervention in epithelial precancerous lesions. Our dual\u2010bioinspired hydrogel, MSA@PGel (macrophage membrane\u2010coated and salvianolic acid B [SAB] \/5\u2010aminolevulinic acid co\u2010loaded liposomes embedded in a polydopamine\u2010based gel), leverages both the powerful wet adhesion of mussels and the immune\u2010targeting capabilities of macrophages. The material's core innovation lies in its dynamic catecholato\u2010Fe\n                    <jats:sup>3+<\/jats:sup>\n                    coordination bonds, which form a robust network with a storage modulus (G\u2032) exceeding 8.8\u00a0kPa higher than that of the base hydrogel (G\u2032 &gt; 2.2\u00a0kPa), thereby demonstrating superior mechanical properties and exceptional mucosal adhesion. This system achieves unprecedented lesion\u2010specific delivery by functionalizing the network with macrophage membranes to exploit VCAM\u20101 overexpression in dysplastic epithelium, thereby overcoming the \u201cmucosal delivery barrier\u201d and ensuring prolonged retention (&gt;3\u00a0h). The programmed intervention specifically targets HIF\u20101\u03b1, a metabolic regulator of malignant transformation. Through SAB\u2010mediated HIF\u20101\u03b1 sequestration, our dynamic network not only effectively disrupts hypoxia adaptation to enhance phototherapy but also triggers a significant apoptotic cascade. In vivo studies confirm significant histological normalization, a significant increase in ROS generation, and excellent biosafety. This work establishes a versatile interfacial bioengineering platform, pioneering a new paradigm for the programmed management of epithelial precancerous states through the synergistic integration of biomaterial design and disease\u2010specific targeting.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504229","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:57:28Z","timestamp":1768399048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7028-2872","authenticated-orcid":false,"given":"Xiaoxian","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oral Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhao","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanjun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-6939","authenticated-orcid":false,"given":"Lingyan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-1063","authenticated-orcid":false,"given":"Lan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211014795"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036691\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5772\/54466"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15140"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368\u2010019\u20100047\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13427"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23534"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.115084"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.603"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12488"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14525"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13060866"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306808"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b03148"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004853"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101788"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08689"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016439\u20107"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021989\u20105"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132909"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604894"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202004407"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010022\u201000928\u2010z"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119588"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002054"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002433\u20104"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119491"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.06.035"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3ra04296k"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973\u2010024\u201013380\u20105"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116045"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147241"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2024.127667"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202000439"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076615"}],"container-title":["Advanced 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