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Herein, a site\u2010specific antibacterial strategy based on a multi\u2010pathway microneedle (MN) patch system is presented for effective treatment of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA)\u2010infected wounds and abscesses. The MN patch co\u2010delivers vancomycin and photoactive black phosphorus quantum dots (BPQDs) encapsulated in macrophage membrane\u2010coated cationic liposomes, thereby integrating antibiotic therapy with phototherapy. Upon light activation, BPQDs generate localized hyperthermia and reactive oxygen species, which synergize with vancomycin to eradicate bacteria and reduce the risk of resistance development. The dissolvable MN array ensures efficient penetration through the skin barrier, enabling targeted and sustained release at the infection site. In vivo, this multi\u2010pathway intervention significantly accelerates wound closure, reduces abscess size, suppresses inflammation, and promotes tissue regeneration by remodeling the infectious microenvironment. Overall, this work demonstrates a promising localized therapeutic platform that harnesses multi\u2010pathway antibacterial mechanisms to combat MDR bacteria and facilitate the healing of drug\u2010resistant skin infections.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504240","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:24:58Z","timestamp":1760181898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Site\u2010Specific Antibacterial Strategy for Multi\u2010Pathway Treatment of Drug\u2010Resistant Skin Infections"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-7734","authenticated-orcid":false,"given":"Lu","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University  Nanjing 211198 P. R. 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