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Currently, the in vivo generating efficiency of ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    and triggering lethal pattern against tumor cells are the greatest challenges. Herein, an ingenious ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    generator (DBTG) is first synthesized by covalently linking reactive oxygen species donor (Nile blue derivative) and nitric oxide donor (arginine analog) in a single molecule to improve production of ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    . Lysosome\u2010targeted DBTG is demonstrated to rapidly generate ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    to induce lysosomal membrane permeabilization and simultaneously trigger pyroptosis and cyclic GMP\u2010AMP synthase\u2010stimulator of interferon gene (cGAS\u2010STING) pathway of tumor cells, dramatically promoting the infiltration of T cells and NK cells, and converting \u201ccold\u201d tumors into \u201chot\u201d tumors. In vitro and in vivo experiments show that DBTG possesses significant anti\u2010tumor efficacy, which not only provides a template for the design of novel drug molecules but also an effective strategy for the reversal of immunosuppressive microenvironment by the powerful inflammation triggered by pyroptosis and the STING pathways.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504394","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:53:06Z","timestamp":1765439586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Ingenious Peroxynitrite Generator Specifically Reversing \u201cCold\u201d Tumors via Pyroptosis and STING Pathways"],"prefix":"10.1002","volume":"15","author":[{"given":"Ruipeng","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shanxi University  Taiyuan P. R. 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