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Conventional wound care approaches frequently prioritize bacterial eradication while overlooking the critical need to modulate inflammation. To address this limitation, we have innovatively developed carrier\u2010free nano\u2010aggregates through the co\u2010precipitation of natural polyphenols (resveratrol and piceatannol) and a porphyrin\u2010based photosensitizer, which function as antibacterial and anti\u2010inflammatory agents, respectively. Significantly, rather than forming a simple mixture, the two components co\u2010assemble via microstructure regulation into a highly ordered architecture exhibiting characteristic J\u2010aggregate features. Specifically, the piceatannol\u2010based aggregates (designated T\n                    <jats:sub>4<\/jats:sub>\n                    PIC NPs) achieved an exceptional photothermal conversion efficiency (PCE) of 51.1% under 730\u00a0nm irradiation, accompanied by an 86\u00a0nm spectral redshift, surpassing most previously reported porphyrin\u2010based nanoparticles. These properties enable highly effective sterilization even at low doses. Notably, the natural polyphenols not only enhance phototherapeutic efficacy but also, owing to their multi\u2010hydroxyl structures, effectively scavenge reactive oxygen species and modulate inflammatory responses, thereby accelerating wound healing. This study establishes a straightforward strategy for delivering natural polyphenolic drugs while concurrently constructing highly efficient porphyrin\u2010based photothermal formulations, demonstrating unique advantages for advanced wound management.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504408","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:29:03Z","timestamp":1771316943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhanced Photothermal Sterilization and Wound Healing Performance Through Natural Polyphenol\u2010Mediated Formation of Porphyrin J\u2010Aggregates"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaohui","family":"Wang","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Advanced Medical Analysis and Public Health Nantong Key Laboratory of Public Health and Medical Analysis School of Public Health Nantong University  Nantong Jiangsu P. 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