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We present an oral, living co\u2010therapy in which viable\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    is vacuum\u2010loaded with intracellular SAL and protected by a pH\u2010responsive Eudragit L100 enteric coat (SAL@AKK@EL100). This construct effectively retains probiotic activity, shields the cargo through gastric transit, and shows prolonged intracellular retention with gradual release. In Dex\u2010challenged zebrafish, SAL@AKK@EL100 reversed behavioral dysregulation and improved skeletal mineralization, outperforming SAL or AKK alone. Integrative RNA\u2010seq\/16S analysis revealed that SAL@AKK@EL100 treatment was\u00a0associated with\u00a0modulation of pathways related to tight junctions, ECM\u2010receptor interaction, actin cytoskeleton, glutathione metabolism, and unsaturated fatty acid biosynthesis, alongside remodeling of the gut microbiota. SAL@AKK@EL100 establishes a modular, microbiome\u2010anchored platform that couples probiotic viability with drug gradual release for promising oral management of GIOP.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504437","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:16:57Z","timestamp":1776057417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Delivery System Based on\n                    <i>Akkermansia Muciniphila<\/i>\n                    Loaded Salidroside for the Treatment of Osteoporosis in Zebrafish Model"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiahui","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Life Sciences &amp; Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou University  Wenzhou 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