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However, the poor antibacterial and angiogenic properties of bioinert PEEK have become a limitation to its clinical application. Therefore, a biomimetic metal organic framework acid\u2010controlled release nanocarrier consisting of Zeolitic Imidazolate Framework\u20108 (ZIF\u20108) nanoparticles loaded with gentamicin and modified with silk fibroin nanospheres for PEEK implants is prepared. In this study, acidity\u2010responsive PEEK implant can efficiently capture bacteria and eradicate bacterial biofilms, achieving antibacterial rates up to 99.9% against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ). Furthermore, acidity\u2010responsive PEEK implant is expected to promote angiogenesis by assisting proliferation and migration of endothelial cells, thereby accelerating peri\u2010implant tissue regeneration. By constructing subcutaneous infection models, it is further indicated that acidity\u2010responsive implant can resist bacterial proliferation and facilitate peri\u2010implant angiogenesis. In summary, this study provided an effective approach for the improvement of orthopedic implants that realized antibacterial and angiogenic effects, offering a potential solution for preventing infection and promoting angiogenesis during the early phase after implantation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504459","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:15:57Z","timestamp":1772990157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silk Fibroin\u2010Modified Metal Organic Framework Acid\u2010Controlled Release Nanocarrier for Polyetheretherketone to Combat Implant\u2010Associated Infections and Promote Angiogenesis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yadi","family":"Su","sequence":"first","affiliation":[{"name":"Department of Dental Implantology, Hospital of Stomatology Jilin University  Jilin 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