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Current oral wound dressings face critical limitations of short protection time due to their weak wet adhesion capability. To address this issue, we developed a Janus bilayer oral wound dressing (P\u2010N\/QCS) with dual functional components. \u200cThe oral cavity\u2010facing surface of the P\u2010N\/QCS film demonstrates effective resistance to salivary erosion, while its opposing surface facilitates integration with biological tissues upon absorption of interfacial fluids or blood. This enables immediate adhesion through physical bonding, subsequently reinforced by molecular entanglement and covalent crosslinking. In vitro tests verified that our dressing exhibited significantly superior wet adhesive strength (53.3 \u00b1 3.7\u00a0kPa). The protective duration of P\u2010N\/QCS exceeded the commercial product Oral Aid by 521.7% (12 \u00b1 0.5\u00a0h vs. 2.3 \u00b1 0.3\u00a0h). Additionally, the Janus dressings showed potent hemostatic capability and excellent antibacterial activity. In the model of rat oral ulcer, the adhesive dressings accelerate the healing of the ulcer by suppressing inflammation and promoting epithelialization. In summary, the Janus bilayer oral wound dressing demonstrates promising clinical potential for oral mucosal repair.<\/jats:p>","DOI":"10.1002\/adhm.202504498","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:07:29Z","timestamp":1766041649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Janus Bilayer Hydrogel Dressing With Enhanced Long\u2010Term Wet Adhesion via Physical\u2010Covalent Synergistic Mechanism for Oral Mucosal Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Xinghui","family":"Gao","sequence":"first","affiliation":[{"name":"Engineering Research Center of Oral Translational Medicine Ministry of Education West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbai","family":"Ju","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Oral Translational Medicine Ministry of Education West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Oral Translational Medicine Ministry of Education West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouzile","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjun","family":"Huo","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Oral Translational Medicine Ministry of Education West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-8885","authenticated-orcid":false,"given":"Min","family":"He","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Oral Translational Medicine Ministry of Education West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Tian","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Oral Translational Medicine Ministry of Education West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"National Engineering Laboratory for Oral Regenerative Medicine West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2157","article-title":"A Scientometric Analysis of Oral Cancer Research in South\/Southeast Asia and China in Oral Diseases","volume":"19","author":"Wei L.","year":"2024","journal-title":"Oral Diseases"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18664"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"N.BhattacharyyaandC.Donald eds. 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