{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:30:53Z","timestamp":1791934253413,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2023\u20100086\/F1"],"award-info":[{"award-number":["2023\u20100086\/F1"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The integration of chemotherapeutics with photothermal immunomodulatory strategies, leveraging a nanotechnology platform, has transformative potential for cancer therapy. In this context, we have designed a novel biomimetic platform by cloaking Palbociclib\u2010loaded mesoporous silica\u2010polypyrrole nanoparticles with homologous cancer cell membranes (CM@SP\u2010PLB NPs). These biomimetic NPs exhibit optimal physicochemical characteristics, including uniform morphology, laser\u2010responsive drug release, and a photothermal efficiency of 57.6%. In vitro assays demonstrate enhanced homotypic cellular uptake, reactive oxygen species (ROsS) generation, mitochondrial dysfunction, and potent cytotoxicity in human and murine oral cancer cells. Additionally, they induce the release of immunogenic cell death (ICD) markers via exposure of the surface marker calreticulin (CALR) and extracellular ATP release. CM@SP\u2010PLB NPs (+L) exhibited superior tumor accumulation, photothermal effects, and increased temperature up to 55\u00b0C, resulting in effective tumor volume regression. In vivo immunomodulation studies showed tumor\u2010associated macrophage repolarization and significant immunomodulatory reprogramming by downregulating immunosuppressive markers while markedly upregulating key pro\u2010inflammatory and antitumor immune genes, thereby enhancing the antitumor immune response. Furthermore, systemic biocompatibility and reduced metastasis further substantiate the nanoplatform's therapeutic potential. Overall, the developed bioinspired nanoplatform offers a chemo\u2010immunomodulatory photothermal strategy for synergistic eradication of tumors in oral cancer.<\/jats:p>","DOI":"10.1002\/adhm.202504519","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:47:38Z","timestamp":1773910058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer Cell Membrane\u2010Coated Nanoparticles for Homotypic Targeting and Photothermal Chemo\u2010Immunomodulatory Therapy of Oral Cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Shishira","family":"P S","sequence":"first","affiliation":[{"name":"Nanomedicine Research Laboratory Department of Pharmacy Birla Institute of Technology &amp; Science\u2010Pilani  Hyderabad Campus Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonmoy","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Nanomedicine Research Laboratory Department of Pharmacy Birla Institute of Technology &amp; Science\u2010Pilani  Hyderabad Campus Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaram","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Nanomedicine Research Laboratory Department of Pharmacy Birla Institute of Technology &amp; Science\u2010Pilani  Hyderabad Campus Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-4206","authenticated-orcid":false,"given":"Swati","family":"Biswas","sequence":"additional","affiliation":[{"name":"Nanomedicine Research Laboratory Department of Pharmacy Birla Institute of Technology &amp; Science\u2010Pilani  Hyderabad Campus Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093168"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_403_18"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2020.603160"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.11.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113676"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4504"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188912"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100300\u2010y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13184"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119787"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1571212"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00891"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13192"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b02786"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b04695"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604488"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.03.012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym8100373"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bsecv.2017.03.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2019.03.125"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213550"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c02056"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05292"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.106700"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c00723"},{"key":"e_1_2_9_29_1","first-page":"1","article-title":"F127\/Chlorin e6\u2010Nanomicelles to Enhance Ce6 Solubility and PDT\u2010Efficacy Mitigating Lung Metastasis in Melanoma","volume":"14","author":"Paul M.","year":"2024","journal-title":"Drug Delivery and Translational Research"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.214121"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114399"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119108"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100841"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA03914C"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10030118"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/658476"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00909.x"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2023-5986"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202153932"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3558"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000613\u20104"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2260625"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010022\u201002376\u20104"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.675664"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:16:48Z","timestamp":1791440208000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":43,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adhm.202504519"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504519","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"2025-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04519"}}