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Herein, an efficient cascade catalytic system is designed by loading folic acid and bovine serum albumin\u2010modified manganese dioxide (MnO\n                    <jats:sub>2<\/jats:sub>\n                    ) onto MXene nanosheets, improving the dispersibility of MXene in physiological environments and endowing it with active targeting capability for folate receptor\u2010overexpressing tumors and O\n                    <jats:sub>2<\/jats:sub>\n                    regeneration capacity. Glucose oxidase (GOx) and L\u2010arginine (L\u2010Arg) are sequentially loaded onto MXene to obtain a cascade catalytic system for anti\u2010cancer applications. MXene can be used to mediate near\u2010infrared light\u2010based photothermal therapy. GOx consumes intracellular glucose and generates hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), which can further oxidize L\u2010Arg to generate nitric oxide and finally achieve synergy between starvation therapy and gas therapy. MnO\n                    <jats:sub>2<\/jats:sub>\n                    decomposes excess H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and generates O\n                    <jats:sub>2<\/jats:sub>\n                    , thus alleviating hypoxic inhibition of the tumor microenvironment and enhancing the effect of starvation therapy. A series of in vivo and ex vivo experiments demonstrates that the developed cascade catalytic system has much better anti\u2010cancer effects with low toxicity and side effects, and successfully synergizes starvation\/gas\/photothermal therapies, which represents a novel, green, and promising strategy for cancer treatment without any chemotherapeutics.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504533","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:11:19Z","timestamp":1764321079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MXene\u2010Based Nanosheets Reverse Tumor Hypoxia to Amplify Triple\u2010Mode Cancer Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Wenzhi","family":"Yang","sequence":"first","affiliation":[{"name":"School of Life Sciences Zhengzhou University  Zhengzhou Henan 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