{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:18:44Z","timestamp":1786976324212,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32401134"],"award-info":[{"award-number":["32401134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The inflammatory cascade initiated by acute spinal cord injury (SCI) is a crucial element contributing to subsequent pathological damage. Uncontrolled or excessive inflammatory responses aggravate neural tissue destruction and hinder the regenerative process. Stimulator of interferons genes (STING) is a key regulator in the innate immune signaling pathway that promotes the generation of inflammatory mediators by activating the TBK1 and IRF3 signaling pathways, thereby shaping the post\u2010injury microenvironment. In this study, we developed a hyaluronic acid\u2010phenylboronic acid\u2010polyvinyl alcohol\u2010based hydrogel (HA\u2010PBA\u2010PVA, termed HPP) as a local delivery vehicle for the STING\u2010specific inhibitor C\u2010176, which was applied directly to the injury epicenter in a rat model of complete spinal cord transection. The locally implanted C\u2010176@HPP can effectively deliver C\u2010176 to the injured site, markedly reducing the expression of pro\u2010inflammatory cytokines by regulating the STING\/TBK1 signaling pathway. Moreover, the administration of C\u2010176@HPP can significantly attenuate microglial activation and promote neuronal survival and axonal regeneration, which eventually contribute to locomotor improvement after SCI. Our findings demonstrate that C\u2010176@HPP provides a promising strategy for ameliorating neuro\u2010inflammation and facilitating neural tissue regeneration after SCI.<\/jats:p>","DOI":"10.1002\/adhm.202504534","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:52:39Z","timestamp":1769755959000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Situ Forming ROS\u2010Scavenging Hydrogel with a STING Inhibitor Improves Recovery After Acute Spinal Cord Injury by Modulating Inflammatory Microenvironment"],"prefix":"10.1002","volume":"15","author":[{"given":"Xigong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyue","family":"Sun","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaipeng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou Medical University  Guiyang Guizhou China"},{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine School of Pharmaceutical Sciences Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou Medical University  Guiyang Guizhou China"},{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine School of Pharmaceutical Sciences Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Xie","sequence":"additional","affiliation":[{"name":"Yuncheng Central Hospital Affiliated to Shanxi Medical University  Yuncheng China"},{"name":"Yuncheng Key Laboratory of Neuromedicine  Yuncheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yuncheng Central Hospital Affiliated to Shanxi Medical University  Yuncheng China"},{"name":"Yuncheng Key Laboratory of Neuromedicine  Yuncheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaju","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7872-2719","authenticated-orcid":false,"given":"Tengfei","family":"Mao","sequence":"additional","affiliation":[{"name":"Yuncheng Central Hospital Affiliated to Shanxi Medical University  Yuncheng China"},{"name":"Yuncheng Key Laboratory of Neuromedicine  Yuncheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00063"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.18"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19638"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00885-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.244796"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.2.319"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00468-w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.02.019"},{"key":"e_1_2_8_12_1","article-title":"Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas\u2010Sting Axis in Spinal Cord Injury","volume":"11","author":"Wei F. L.","year":"2024","journal-title":"Advancement of Science"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70390"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111348"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.07.125"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202301173"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313672"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c12013"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0296-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300123"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.350212"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0495"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.09.019"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115803"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2996"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308331110"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090549"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02337-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.04.029"},{"key":"e_1_2_8_30_1","article-title":"Novel Nerve Regeneration Assessment Method Using Adult Zebrafish With Crush Spinal Cord Injury","author":"Motohashi H.","year":"2024","journal-title":"Journal of Comparative Physiology A, Neuroethology, Sensory, Neural, and Behavioral Physiology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.84564"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.07.034"},{"key":"e_1_2_8_33_1","first-page":"24","article-title":"Mesenchymal Stem Cell Therapy in Traumatic Spinal Cord Injury: A Systematic Review","author":"Montoto\u2010Meijide R.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0631-6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c13671"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S152246"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-021-10031-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2630"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03151-1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49199"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1256"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060853"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.068"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504534","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:10:33Z","timestamp":1783012233000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":42,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/adhm.202504534"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504534","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04534"}}