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Here, a photothermal\u2010driven nanoplatform (denoted as HCPH) was developed to regulate subcellular calcium ion translocation, induce mitochondrial dysfunction, and enhance PTT efficacy. Specifically, HCPH is based on hollow mesoporous Prussian blue nanoparticles (HMPB NPs), which are loaded with curcumin (CUR) and modified with hyaluronic acid (HA) on their surface. Under near\u2010infrared (NIR) laser irradiation, it exhibited excellent photothermal conversion efficiency, targeted tumor cells via CD44\u2010mediated endocytosis, and released CUR under acidic conditions. Notably, CUR induced endoplasmic reticulum (ER) Ca\n                    <jats:sup>2<\/jats:sup>\n                    \u207a release and inhibited HSP90, while the photothermal effect of HCPH activated the TRPV1 calcium channel on the cell membrane to promote Ca\n                    <jats:sup>2<\/jats:sup>\n                    \u207a influx. The dual\u2010pathway synergy caused cytoplasmic and mitochondrial Ca\n                    <jats:sup>2<\/jats:sup>\n                    \u207a overload, leading to mitochondrial dysfunction and reduced ATP synthesis, which further inhibited HSP90 expression and formed a \u201cPTT\u2010calcium disorder\u2010enhanced PTT\u201d cycle. In vitro and in vivo experiments confirm that HCPH significantly improved tumor therapeutic efficacy through photothermal\u2010driven subcellular calcium translocation regulation and mitochondrial damage.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504541","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T05:14:28Z","timestamp":1768194868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Photothermal\u2010Driven Subcellular Calcium Ion Translocation and Mitochondrial Dysfunction for Augmented Tumor Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiayi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Translational Medicine Center Beijing Chest Hospital\/Beijing Tuberculosis and Thoracic Tumor Research Institute Capital Medical University  Beijing 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