{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:15:56Z","timestamp":1788509756887,"version":"build-2803163510"},"reference-count":169,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Premature ovarian insufficiency (POI) is a complex endocrine disorder characterized by the loss of ovarian function before age 40, leading to infertility, hypoestrogenism, and systemic complications. Conventional hormone replacement therapies (HRTs) offer only partial relief, failing to replicate the dynamic feedback of endogenous hormone regulation. Advances in tissue engineering, stem cell technology, and microphysiological systems have catalyzed the development of bioengineered platforms that mimic native ovarian endocrine function. This review outlines progress from three\u2010dimensional (3D) follicle\u2010mimetic constructs and scaffold\u2010free organoids to dynamic ovary\u2010on\u2010a\u2010chip systems, emphasizing advances in steroidogenesis reconstitution, innovations in granulosa\u2010theca co\u2010cultures, and the design of cell\u2010based hormone replacement therapies (cHRTs) capable of re\u2010engaging the hypothalamic\u2010pituitary\u2010ovarian (HPO) axis. We also address critical translational challenges including immunoisolation, vascularization, and regulatory pathway. By bridging bioengineering and reproductive medicine, cHRTs represent a paradigm shift, offering the potential to restore endocrine health, fertility, and systemic homeostasis in a personalized and physiologically relevant manner.<\/jats:p>","DOI":"10.1002\/adhm.202504580","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:06:27Z","timestamp":1782194787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioengineering Ovarian Endocrine Function: From Follicle Modeling to Cell\u2010Based Hormone Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Maria Jo\u00e3o","family":"Sousa","sequence":"first","affiliation":[{"name":"P\u00f4le De Recherche en Physiopathologie de La Reproduction Instituite of Experimental and Clinique Research Universit\u00e9 Catholique De Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-0368","authenticated-orcid":false,"given":"Christiani A.","family":"Amorim","sequence":"additional","affiliation":[{"name":"P\u00f4le De Recherche en Physiopathologie de La Reproduction Instituite of Experimental and Clinique Research Universit\u00e9 Catholique De Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2019.1574738"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076566"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11217"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.164"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15261"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u20100259\u20103"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev052"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14584"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-017-1823-7"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002258\u20107"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2025.103639"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.08.026"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2026.101209"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000325\u20102"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000325\u20102"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12124042"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2023.107871"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew027"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054423"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60355-8"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag031"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1160258"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010024\u201001555\u20105"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00529"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.366"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/RAF\u201021\u20100014"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010022\u201000913\u20106"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010024\u201001254\u20102"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa782"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010023\u201002981\u2010y"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201038754\u2010x"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.998424"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010026\u201002040\u2010x"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.21451\/1984\u20103143\u2010AR2018\u20100087"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.19.17585"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2875"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.22165"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD13293"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.078386"},{"key":"e_1_2_14_41_1","first-page":"94","article-title":"Function of MicroRNAs in Normal and Abnormal Ovarian Activities: A Review Focus on MicroRNA\u201021","volume":"18","author":"Arefnezhad R.","year":"2024","journal-title":"International Journal of Fertility & Sterility"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010017\u20100163\u20108"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29725"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4036"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201001811\u2010z"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa127"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8069898"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.5493\/wjem.v14.i2.88867"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052594"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010021\u201001343\u2010z"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa008"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms022"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1025018"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207792"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277052"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.06.027"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.08.013"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00943"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518807100"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2019.06.003"},{"key":"e_1_2_14_61_1","first-page":"161","volume-title":"Associations Between Exposure to Cadmium, Lead, Mercury and Mixtures and Women's Infertility and Long\u2010term Amenorrhea","author":"McClam M.","year":"2023"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105710"},{"key":"e_1_2_14_63_1","first-page":"1466967","volume-title":"Endocrine Disruptor Chemicals Exposure and Female Fertility Declining: From Pathophysiology to Epigenetic Risks","author":"Tricotteaux\u2010Zarqaoui S.","year":"2024"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2023.102449"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13114"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.05.029"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000832"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20108\u201041"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-92589-5_6"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.11.012"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12371"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121479"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1268248"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107827\u201012\u2010128"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221110"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081851"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010174"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1210503"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112799361945"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10020367"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.059"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4030"},{"key":"e_1_2_14_83_1","first-page":"12","volume-title":"Directed Differentiation of Human iPSCs to Functional Ovarian Granulosa\u2010Like Cells via Transcription Factor Overexpression","author":"Pierson Smela M. D.","year":"2023"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2025.12.020"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.054"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10050550"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010026\u201002079\u2010w"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad014"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202419977"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2021.1968542"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010017\u20101836\u20102"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282221094193"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34974"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-026-00371-z"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010010\u20109468\u20106"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010025\u201003432\u20106"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1310696"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58111565"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25934-4"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.104450"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa100"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der468"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den343"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.054833"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.071142"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.001"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169494"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/10_2021_168"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14050355"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0307"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(16)53813\u20108"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0770171"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.74.4.1548349"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5191"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83291"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa246"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u20100760(97)00030\u20107"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010019\u201000099\u20100"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13849"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1260527"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod43.5.726"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/abbd29"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0684"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c18734"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2008.09.002"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.07.004"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001851\u20103"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010019\u201002334\u2010w"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi12030261"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010020\u201000445\u20107"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe8873"},{"key":"e_1_2_14_132_1","first-page":"45","article-title":"In Vitro Steroidogenesis by Granulosa Cells From Equine Pre\u2010Ovulatory Follicles","volume":"44","author":"Tucker K. E.","year":"1991","journal-title":"Journal of Reproduction and Fertility Supplement"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.2527\/1996.74123012x"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098\u20102795(199806)50:2<170::AID\u2010MRD7>3.0.CO;2\u2010H"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.23.746"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod27.3.641"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo\u2010125\u20101\u2010321"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202511098"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20246"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD9960259"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632703322495655"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.2478\/acb\u20102022\u20100006"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2021.01.008"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod38.4.881"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.709"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2016.0410"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2023.03.002"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70333"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439\u2010023\u201003307\u2010w"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-017-0161-x"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13619\u2010022\u201000125\u20108"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20104302"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115010"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1557\/s43579\u2010024\u201000678\u20106"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.869984"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1391504"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010022\u201000790\u20104"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040469"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv6348"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004172"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010019\u20100106\u20103"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.653088"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.662084"},{"key":"e_1_2_14_164_1","volume-title":"Engineering an Immuno\u2010Isolating Hydrogel\u2010Based Capsule to Restore Ovarian Endocrine Function","author":"Day J.","year":"2020"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2026.1735871"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa156"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731419884708"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9750"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.07.031"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.038"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:49:10Z","timestamp":1788508150000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":169,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/adhm.202504580"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504580","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04580"}}