{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:21:04Z","timestamp":1790025664717,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20230807111120043"],"award-info":[{"award-number":["JCYJ20230807111120043"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endometritis, a common gynecological disease caused by ascending bacterial infection, is a leading cause of infertility. Currently, the clinical treatment relies primarily on antibiotic therapy, administered via intravenous injection, oral administration, or local delivery (e.g., intrauterine infusion). Nevertheless, intravenous injection aggravates hepatic and renal burdens, whereas oral administration elicits gastrointestinal reactions; intrauterine infusion suffers from drug leakage from the uterus due to gravity. Therefore, we developed mucoadhesive doxycycline hydrochloride\u2010loaded air microbubbles (Mad\u2010Doxy\u2010MBs) for intrauterine infusion therapy of endometritis to overcome these limitations. The results showed that Mad\u2010Doxy\u2010MBs exhibited an ultrasound contrast\u2010enhancement property so that they could be tracked by clinicians under ultrasound to achieve their precise localization on the endometrium when infused transvaginally. Subsequently, Mad\u2010Doxy\u2010MBs adhered to the endometrial surface and continuously released Doxy, exhibiting robust bactericidal and anti\u2010inflammatory capacities. Compared with daily oral Doxy administration, two once\u2010weekly intrauterine infusions of Mad\u2010Doxy\u2010MBs achieved superior therapeutic efficacy against endometritis while exhibiting markedly lower gastrointestinal toxicity. This drug delivery platform that integrates the properties of ultrasound visualization, mucoadhesion, and sustained drug release offers a clinically translatable strategy for intrauterine infusion therapy of endometritis and opens new avenues for precise and long\u2010term drug delivery in other luminal diseases.<\/jats:p>","DOI":"10.1002\/adhm.202504676","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:35:22Z","timestamp":1770096922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mucoadhesive Air Microbubbles With Sustained Antibiotic Release for Ultrasound\u2010Guided Intrauterine Infusion Therapy of Endometritis"],"prefix":"10.1002","volume":"15","author":[{"given":"Tianmin","family":"Tang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine The Sixth Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiurong","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanshuan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-8679","authenticated-orcid":false,"given":"Jianhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.04.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.03.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414792"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.12.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.02.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.03.074"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000658\u20105"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.12.083"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmae013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.031"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1614626"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001067.pub3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.03.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001257\u20104"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01892\u201024"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010023\u201003004\u20104"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2022.11.004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13177"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010018\u20100688\u20108"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201095072\u2010w"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010022\u201002128\u20108"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.01.010"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2bm01586b"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427\u2010018\u20100066\u2010x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.018"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120366"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010018\u20101368\u20101"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.02.044"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b01632"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2016.02.013"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.12.047"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211934"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.16677"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.983712"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504676","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:13:43Z","timestamp":1777029223000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":37,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/adhm.202504676"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504676","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04676"}}