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Despite its high prevalence, current therapeutic interventions for AGA remain constrained by prolonged treatment durations, notable safety risks, and prohibitive expenses. To address these limitations, we engineered\u00a0detachable microneedles incorporating TEMPO\u2010oxidized chitin derivatives (CD MNs), which demonstrated unprecedented hair regenerative capacity. In C57BL\/6j AGA models, CD MNs induced 71.56%\u00a0\u00b1\u00a014.20% hair regrowth density at day 16 (vs. 32.23%\u00a0\u00b1\u00a014.55% for 5% minoxidil,\n                    <jats:bold>t<\/jats:bold>\n                    he current clinical gold standard).\n                    <jats:italic>Ex vivo<\/jats:italic>\n                    AGA hair follicle exhibited 0.93\u00a0\u00b1\u00a00.15\u00a0mm hair shaft elongation under chitin derivatives treatment within 5 days, which is comparable to minoxidil. Mechanistic profiling via single\u2010cell RNA sequencing identified CD MNs mediated suppression of lysosomal hydrolases and membrane proteins, indicating autophagy potentiation. Further ex vivo studies confirmed that chitin derivatives promoted hair growth by activating the hair follicle autophagy.\u00a0Notably, the microneedle system exhibited no detectable dermal or visceral toxicity. To our knowledge, this study is the first to report the anti\u2010AGA activity of chitin derivatives. Our findings established a robust theoretical foundation and preclinical validation for chitin\u2010based biomaterials as next\u2010generation AGA therapies, offering a safe, cost\u2010effective alternative to conventional therapies.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504691","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:12:19Z","timestamp":1775805139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chitin Derivative\u2010Based Detachable Microneedles for Effective Treatment of Androgenic Alopecia"],"prefix":"10.1002","volume":"15","author":[{"given":"Jiaxue","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8940-4316","authenticated-orcid":false,"given":"Qingqing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiye","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center Xi'an Jiaotong University  Xi'an China"},{"name":"The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c22814"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_47_24"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14624"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2010.09777.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010019\u201000479\u2010x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044\u20108295.1995.tb02756.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202201293"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1009"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"31","article-title":"Finasteride for Hair Loss: A Review","volume":"33","author":"Gupta A. 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