{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:26:11Z","timestamp":1787505971886,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171103"],"award-info":[{"award-number":["82171103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Uveitis is a prevalent ocular inflammatory condition and a major contributor to global vision impairment. The inflammatory cascade activates the complement system, resulting in the production of C5a, which interacts with its receptor C5aR1 on microglia, promoting excessive neutrophil recruitment and reactive oxygen species (ROS) bursts. In this study, we develop a targeted drug delivery system by conjugating small extracellular vesicles with the microglia\u2010binding peptide MG1 using Sortase A. The C5aR1 antagonist Avacopan was loaded into the modified EVs via extrusion. Using a lipopolysaccharide (LPS)\u2010induced endotoxin\u2010induced uveitis (EIU) model, we evaluate the effects of MG1\u2010EVs\/Ava on ocular inflammatory pathology, microglial migration, and retinal cytokine expression. In vitro assays are performed to assess the cytotoxicity of Avacopan as well as its impact on ROS generation and pro\u2010inflammatory cytokine production. In addition, data\u2010independent acquisition (DIA) proteomics analysis is conducted to explore the downstream signaling pathways involved in MG1\u2010EVs\/Ava\u2010mediated therapeutic effects. In rescue experiments, siRNA\u2010mediated knockdown of MAPK9 reverses the downregulation of C5aR1 and pro\u2010inflammatory cytokines, further supporting its role in mediating the therapeutic effects of MG1\u2010EVs\/Ava. The findings of this study demonstrate both the therapeutic efficacy and mechanistic basis of MG1\u2010EVs\/Ava, highlighting its potential as a promising treatment strategy for infectious uveitis.<\/jats:p>","DOI":"10.1002\/adhm.202504723","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T06:43:01Z","timestamp":1769323381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeted Delivery of Avacopan via Sortase A\u2013Modified Extracellular Vesicles Attenuates Endotoxin\u2010Induced Retinal Inflammation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-7594","authenticated-orcid":false,"given":"Dexin","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The Second Affiliated Hospital of Harbin Medical University Harbin Medical University  Harbin P. R. 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