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Adequate and inclusive strategies are needed to address these challenges comprehensively. In this study, a whole\u2010course\u2010repair wound dressing (BC\/HA) was simply fabricated to enhance diabetic wound closure. The BC\/HA wound dressing, created by combining bovine colostrum (BC) with hyaluronic acid solution (HA), demonstrated good cytocompatibility, endothelial cell migration, angiogenesis, and antibiofilm effects. Using a full\u2010thickness diabetic wound model, we found that the BC\/HA dressing effectively modulated the diabetic wound microenvironment. Specifically, it facilitated the conversion of pro\u2010inflammatory M1 macrophages to pro\u2010regenerative M2 macrophages at a rate twice that of the control group. This transformation subsequently promoted endothelial cell migration to the wound sites during the inflammatory phase, resulting in over a 3.8\u2010fold enhancement in vascular formation during the proliferation phase. Furthermore, the BC\/HA wound dressing promoted re\u2010epithelialization and facilitated the formation of dermal appendages, hair follicles, and glands in the remodeling phase. These findings shed light on the potential of the BC\/HA wound dressing as a promising platform for chronic wound regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202504734","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:15:44Z","timestamp":1768893344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Whole\u2010Course\u2010Repair Wound Dressing Based on Bovine Colostrum and Hyaluronic Acid for Diabetic Wound Repair Through Immunomodulation, Angiogenesis, and Re\u2010Epithelization"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3111-517X","authenticated-orcid":false,"given":"Caihong","family":"Xian","sequence":"first","affiliation":[{"name":"The Affiliated Qingyuan Hospital (Qingyuan People's Hospital) Guangzhou Medical University  Qingyuan China"},{"name":"Department of OrthopedicsDepartment of Hematology The Seventh Affiliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of OrthopedicsDepartment of Hematology The Seventh Affiliated Hospital Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Du","sequence":"additional","affiliation":[{"name":"Bioscience and Biomedical Engineering Thrust Systems Hub The Hong Kong University of Science and Technology (Guangzhou)  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"You","sequence":"additional","affiliation":[{"name":"The Affiliated Qingyuan Hospital (Qingyuan People's Hospital) Guangzhou Medical University  Qingyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Affiliated Qingyuan Hospital 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