{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:09:31Z","timestamp":1789560571099,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301172"],"award-info":[{"award-number":["32301172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Current vitreous substitutes, failing to recapitulate the dynamic proteomic microenvironment essential for retinal homeostasis, often cause complications like increased intraocular pressure, proliferative vitreoretinopathy and macular edema. Herein, we propose a proteome\u2010directed vitreous microenvironment engineering strategy, pioneering a paradigm that goes beyond structural replacement by actively restoring the proteomic homeostasis intrinsic to the native vitreous. Specifically, a photo\u2010crosslinked network is engineered by integrating hyaluronic acid methacrylate and polyethylene glycol methacrylate, achieving exceptional (&gt;90%) retention of endogenous vitreous proteins (e.g., COL2A1, COL3A1, FBLN1, FBLN2). This engineered vitreous\u2010mimetic properties, featuring high optical transmittance, a physiological refractive index and tailored viscoelasticity. Crucially, small\u2010angle X\u2010ray scattering reveals a dual\u2010mesh architecture (\u03be = 13\u201347.5\u00a0nm) of the network, facilitating selective diffusion of small molecules while immobilizing homeostatic proteins. In a rabbit vitrectomy model, this network exhibits long\u2010term structural stability in supporting retina, demonstrates good biocompatibility, and preserves the endogenous vitreous proteome without causing observable adverse effects. This work introduces a promising platform for intraocular biomaterial design by integrating proteomic functionality to dynamically form a homeostatic microenvironment, offering a safe intraocular tamponade for vitreoretinal pathologies.<\/jats:p>","DOI":"10.1002\/adhm.202504836","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T10:11:03Z","timestamp":1766743863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinspired Proteome\u2010Engineered Hydrogels as Vitreous Substitutes for Preserving Intraocular Homeostasis"],"prefix":"10.1002","volume":"15","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology West China Hospital Sichuan University  Chengdu P. R. 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