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Current treatment methods are compromised by a narrow therapeutic window, risk of ischemia\u2010reperfusion injury, rapid systemic drug clearance, and inadequate targeting efficiency. To address these limitations, we developed an innovative multifunctional biomimetic nano\u2010therapeutic system (PDMC\/CHP@S\/V), which comprised a triblock copolymer synthesized through controlled polymerization of dopamine methacrylamide (DMA), 2\u2010methacryloyloxyethyl phosphorylcholine (MPC), and methacrylate\u2010functionalized cyclodextrin. Adamantane\u2010conjugated cardiac homing peptide was anchored onto the nanoparticles surface via host\u2010guest interactions, enabling precise infarct\u2010targeting drug delivery. The cell membrane\u2010like MPC shell markedly reduced macrophage\u2010mediated phagocytosis, prolonging circulation time, while the catechol groups in DMA provided robust antioxidant effects by scavenging reactive oxygen species (ROS). The in vitro experiments showed that the nanosystem effectively reduced ROS level, alleviated cell apoptosis, and restored mitochondrial membrane potential in hypoxic cardiomyocytes. Furthermore, the in vivo tests indicated that PDMC\/CHP@S\/V significantly improved cardiac function, as evidenced by a remarkable reduction of myocardial fibrosis and attenuated ventricular remodeling in AMI mice model. 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