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These systems serve as bioengineerable platforms with diverse architectures and customizable properties, enabling advances in both basic and translational neuroscience. Despite rapid adoption across neurodevelopment, neurodegeneration, and neuro\u2010oncology, the field remains fragmented, with substantial methodological variability and no standardized framework for model selection. A systematic review of 738 original studies published between 2014 and 2024, drawn from 3631 articles across PubMed, Semantic Scholar, and OpenAlex, reveals that human induced pluripotent stem cell\u2010derived cerebral organoids and neurodevelopmental studies dominate the field. In contrast, applications in neurodegeneration, brain metastases, and non\u2010human systems remain limited, narrowing the translational scope. To address the challenge of navigating this expanding literature,\n                    <jats:italic>OrganoidMap<\/jats:italic>\n                    is introduced\u2014an open\u2010access, interactive web platform for exploring, filtering, and comparing cerebral organoid models across disease areas, cell sources, and methodological features.\n                    <jats:italic>OrganoidMap<\/jats:italic>\n                    enables the identification of appropriate models for specific experimental goals and reveals underexplored research areas. This synthesis establishes a scalable foundation for enhancing transparency, reproducibility, and model selection in organoid\u2010based research, setting a new benchmark for how neuroscience and biomaterials communities organize, share, and advance cerebral organoid science.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504889","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:51:59Z","timestamp":1773237119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience"],"prefix":"10.1002","volume":"15","author":[{"given":"Anna","family":"Wolfram","sequence":"first","affiliation":[{"name":"Department of Neurology and Interdisciplinary Neurooncology Hertie Institute for Clinical Brain Research University Hospital T\u00fcbingen  T\u00fcbingen Germany"},{"name":"M3 Research 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