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Transitioning the wound environment from pro\u2010inflammatory to regenerative states requires precise modulation of macrophages and supporting cell activities. Although electrical stimulation (ES) has been highlighted as a novel approach to modulate inflammatory reactions and treat chronic wounds, conventional electroceuticals face translational hurdles due to undefined optimal parameters and technical limitations of ES devices. In this study, we screened and identified key ES parameters that attenuate prolonged inflammation and promote a regenerative immune environment for chronic wound treatment. To enable successful translation of optimized ES conditions, we fabricated a spray\u2010printed conductive ink\u2010based electroceutical (SCOPE) patch composed of polyvinyl alcohol (PVA) and liquid metal (LM), enabling highly conductive, stable ES delivery at dynamic wound sites. In an animal study using a diabetic mouse wound model, application of the electroceutical patch suppressed local inflammation and enhanced tissue regeneration through re\u2010epithelialization and neovascularization. Collectively, our functional and mechanistic investigations of ES conditions, together with their implementation via an electroceutical patch, suggest an effective therapeutic platform for modulating immune responses and promoting wound healing under chronic inflammatory conditions.<\/jats:p>","DOI":"10.1002\/adhm.202504939","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T13:46:34Z","timestamp":1767620794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimized Electrical Stimulation Using a Spray\u2010Printed Conductive Electroceutical Patch for Accelerated Wound Healing in Diabetic Mice"],"prefix":"10.1002","volume":"15","author":[{"given":"Jung Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Intelligent Precision Healthcare Convergence Sungkyunkwan University (SKKU)  Suwon Republic of 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