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Traditional dressings often do not address these interrelated issues effectively. In this study, we present a multifunctional composite sponge created by integrating curcumin\u2010modified mesoporous ceria nanoparticles (CeO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010cur) into a scaffold made from acellular dermal matrix (ADM) and poly(vinyl alcohol) (PVA). This scaffold is designed to simultaneously manage exudate, combat bacterial infections, and modulate the inflammatory environment. The developed scaffold exhibits a high swelling ratio and excellent fluid retention, ensuring a balanced moist environment that promotes healing. In vitro studies revealed its strong antibacterial activity against both\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , as well as its ability to enhance cell adhesion and migration, and effectively shift macrophages from a pro\u2010inflammatory M1 to a pro\u2010repair M2 phenotype. When applied to full\u2010thickness wounds in a diabetic mouse model, this dressing significantly accelerated wound closure, improved angiogenesis, and facilitated organized collagen deposition. Safety assessments indicated no adverse effects. This research demonstrates a synergistic therapeutic strategy that combines multiple essential functions into a single platform, offering a promising approach for the clinical management of chronic diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504948","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:06:33Z","timestamp":1765962393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic Immuno\u2010Antimicrobial Spongy Scaffold Heals Chronic Diabetic Wounds"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7457-5224","authenticated-orcid":false,"given":"Feixiang","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Dermatology Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8228-4603","authenticated-orcid":false,"given":"Zhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Huiqiao Medical Center Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liujun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-6880","authenticated-orcid":false,"given":"Xu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"28","article-title":"The national and provincial prevalence and non\u2010fatal burdens of diabetes in China from 2005 to 2023 with projections of prevalence to 2050","volume":"12","author":"Zhou Y. 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